Disposition of PCB 11 in Mice following Acute Oral Exposure

Chun Yun Zhang, Carolyn R. Klocke, Pamela J. Lein, Hans Joachim Lehmler

Research output: Contribution to journalArticlepeer-review

Abstract

PCB 11 (3,3′-dichloro-biphenyl) is an emerging environmental contaminant that represents a public health concern. Here, we investigated the distribution of PCB 11 and its metabolites in mice exposed orally to PCB 11. PCB 11 tissue levels followed the rank order adipose > lung ∼muscle > liver > brain > blood 4 h after PCB 11 exposure, which varied from the rank order predicted with a composition-based model. We detected hydroxylated and sulfate metabolites in the liver and sulfate and glucuronide metabolites in serum. These findings lay the groundwork for future toxicity studies with PCB 11.

Original languageEnglish (US)
JournalChemical Research in Toxicology
DOIs
StateAccepted/In press - 2021

ASJC Scopus subject areas

  • Toxicology

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