Abstract
An injectable preparation of flunixin meglumine was administered orally and intravenously at a dose of 1.1 mg/kg to six healthy adult horses in a cross-over design. Flunixin meglumine was detected in plasma within 15 min of administration and peak plasma concentrations were observed 45-60 min after oral administration. Mean bioavailability of the oral drug was 71.9 ± 26.0%, with an absorption half-life of 0.76 h. The apparent elimination half-life after oral administration was 2.4 h. The injectable preparation of flunixin meglumine is suitable for oral administration to horses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 183-186 |
| Number of pages | 4 |
| Journal | Journal of Veterinary Pharmacology and Therapeutics |
| Volume | 27 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 2004 |
| Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology
- veterinary(all)
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Cite this
Pellegrini-Masini, A., Poppenga, R. H., & Sweeney, R. W. (2004). Disposition of flunixin meglumine injectable preparation administered orally to healthy horses. Journal of Veterinary Pharmacology and Therapeutics, 27(3), 183-186. https://doi.org/10.1111/j.1365-2885.2004.00575.x