Disposition of flunixin meglumine injectable preparation administered orally to healthy horses

A. Pellegrini-Masini, Robert H Poppenga, R. W. Sweeney

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

An injectable preparation of flunixin meglumine was administered orally and intravenously at a dose of 1.1 mg/kg to six healthy adult horses in a cross-over design. Flunixin meglumine was detected in plasma within 15 min of administration and peak plasma concentrations were observed 45-60 min after oral administration. Mean bioavailability of the oral drug was 71.9 ± 26.0%, with an absorption half-life of 0.76 h. The apparent elimination half-life after oral administration was 2.4 h. The injectable preparation of flunixin meglumine is suitable for oral administration to horses.

Original languageEnglish (US)
Pages (from-to)183-186
Number of pages4
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume27
Issue number3
DOIs
StatePublished - Jun 2004
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

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