Abstract
An injectable preparation of flunixin meglumine was administered orally and intravenously at a dose of 1.1 mg/kg to six healthy adult horses in a cross-over design. Flunixin meglumine was detected in plasma within 15 min of administration and peak plasma concentrations were observed 45-60 min after oral administration. Mean bioavailability of the oral drug was 71.9 ± 26.0%, with an absorption half-life of 0.76 h. The apparent elimination half-life after oral administration was 2.4 h. The injectable preparation of flunixin meglumine is suitable for oral administration to horses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 183-186 |
| Number of pages | 4 |
| Journal | Journal of Veterinary Pharmacology and Therapeutics |
| Volume | 27 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 2004 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
- veterinary(all)
Cite this
Disposition of flunixin meglumine injectable preparation administered orally to healthy horses. / Pellegrini-Masini, A.; Poppenga, Robert H; Sweeney, R. W.
In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 27, No. 3, 06.2004, p. 183-186.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Disposition of flunixin meglumine injectable preparation administered orally to healthy horses
AU - Pellegrini-Masini, A.
AU - Poppenga, Robert H
AU - Sweeney, R. W.
PY - 2004/6
Y1 - 2004/6
N2 - An injectable preparation of flunixin meglumine was administered orally and intravenously at a dose of 1.1 mg/kg to six healthy adult horses in a cross-over design. Flunixin meglumine was detected in plasma within 15 min of administration and peak plasma concentrations were observed 45-60 min after oral administration. Mean bioavailability of the oral drug was 71.9 ± 26.0%, with an absorption half-life of 0.76 h. The apparent elimination half-life after oral administration was 2.4 h. The injectable preparation of flunixin meglumine is suitable for oral administration to horses.
AB - An injectable preparation of flunixin meglumine was administered orally and intravenously at a dose of 1.1 mg/kg to six healthy adult horses in a cross-over design. Flunixin meglumine was detected in plasma within 15 min of administration and peak plasma concentrations were observed 45-60 min after oral administration. Mean bioavailability of the oral drug was 71.9 ± 26.0%, with an absorption half-life of 0.76 h. The apparent elimination half-life after oral administration was 2.4 h. The injectable preparation of flunixin meglumine is suitable for oral administration to horses.
UR - http://www.scopus.com/inward/record.url?scp=3042832073&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3042832073&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2885.2004.00575.x
DO - 10.1111/j.1365-2885.2004.00575.x
M3 - Article
VL - 27
SP - 183
EP - 186
JO - Journal of Veterinary Pharmacology and Therapeutics
JF - Journal of Veterinary Pharmacology and Therapeutics
SN - 0140-7783
IS - 3
ER -