Disposition of flunixin meglumine injectable preparation administered orally to healthy horses

A. Pellegrini-Masini, Robert H Poppenga, R. W. Sweeney

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

An injectable preparation of flunixin meglumine was administered orally and intravenously at a dose of 1.1 mg/kg to six healthy adult horses in a cross-over design. Flunixin meglumine was detected in plasma within 15 min of administration and peak plasma concentrations were observed 45-60 min after oral administration. Mean bioavailability of the oral drug was 71.9 ± 26.0%, with an absorption half-life of 0.76 h. The apparent elimination half-life after oral administration was 2.4 h. The injectable preparation of flunixin meglumine is suitable for oral administration to horses.

Original languageEnglish (US)
Pages (from-to)183-186
Number of pages4
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume27
Issue number3
DOIs
StatePublished - Jun 2004
Externally publishedYes

Fingerprint

flunixin
oral administration
Horses
Oral Administration
horses
Injections
half life
Half-Life
Cross-Over Studies
Biological Availability
bioavailability
mouth
drugs
dosage
Pharmaceutical Preparations
flunixin meglumine

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

Cite this

Disposition of flunixin meglumine injectable preparation administered orally to healthy horses. / Pellegrini-Masini, A.; Poppenga, Robert H; Sweeney, R. W.

In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 27, No. 3, 06.2004, p. 183-186.

Research output: Contribution to journalArticle

@article{78875fec898f4b7e8e2ce0c51f59113d,
title = "Disposition of flunixin meglumine injectable preparation administered orally to healthy horses",
abstract = "An injectable preparation of flunixin meglumine was administered orally and intravenously at a dose of 1.1 mg/kg to six healthy adult horses in a cross-over design. Flunixin meglumine was detected in plasma within 15 min of administration and peak plasma concentrations were observed 45-60 min after oral administration. Mean bioavailability of the oral drug was 71.9 ± 26.0{\%}, with an absorption half-life of 0.76 h. The apparent elimination half-life after oral administration was 2.4 h. The injectable preparation of flunixin meglumine is suitable for oral administration to horses.",
author = "A. Pellegrini-Masini and Poppenga, {Robert H} and Sweeney, {R. W.}",
year = "2004",
month = "6",
doi = "10.1111/j.1365-2885.2004.00575.x",
language = "English (US)",
volume = "27",
pages = "183--186",
journal = "Journal of Veterinary Pharmacology and Therapeutics",
issn = "0140-7783",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Disposition of flunixin meglumine injectable preparation administered orally to healthy horses

AU - Pellegrini-Masini, A.

AU - Poppenga, Robert H

AU - Sweeney, R. W.

PY - 2004/6

Y1 - 2004/6

N2 - An injectable preparation of flunixin meglumine was administered orally and intravenously at a dose of 1.1 mg/kg to six healthy adult horses in a cross-over design. Flunixin meglumine was detected in plasma within 15 min of administration and peak plasma concentrations were observed 45-60 min after oral administration. Mean bioavailability of the oral drug was 71.9 ± 26.0%, with an absorption half-life of 0.76 h. The apparent elimination half-life after oral administration was 2.4 h. The injectable preparation of flunixin meglumine is suitable for oral administration to horses.

AB - An injectable preparation of flunixin meglumine was administered orally and intravenously at a dose of 1.1 mg/kg to six healthy adult horses in a cross-over design. Flunixin meglumine was detected in plasma within 15 min of administration and peak plasma concentrations were observed 45-60 min after oral administration. Mean bioavailability of the oral drug was 71.9 ± 26.0%, with an absorption half-life of 0.76 h. The apparent elimination half-life after oral administration was 2.4 h. The injectable preparation of flunixin meglumine is suitable for oral administration to horses.

UR - http://www.scopus.com/inward/record.url?scp=3042832073&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042832073&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2885.2004.00575.x

DO - 10.1111/j.1365-2885.2004.00575.x

M3 - Article

VL - 27

SP - 183

EP - 186

JO - Journal of Veterinary Pharmacology and Therapeutics

JF - Journal of Veterinary Pharmacology and Therapeutics

SN - 0140-7783

IS - 3

ER -