Disposition of cyclosporine after intravenous and multi-dose oral administration in cats

M. L. Mehl, A. E. Kyles, A. L. Craigmill, Steven E Epstein, C. R. Gregory

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The aim of this study was to evaluate the disposition of cyclosporine after intravenous (i.v.) and oral administration and to evaluate single sampling times for therapeutic monitoring of cyclosporine drug concentrations in cats. Six adult male cats (clinically intact) were used. Two treatments consisting of a single i.v. cyclosporine (1 mg/kg) and multiple oral cyclosporine (3 mg/kg b.i.d p.o. for 2 weeks) doses. Whole blood cyclosporine concentrations were measured at fixed times by high performance liquid chromatography and pharmacokinetic values were calculated. Mean values for the i.v. data included AUC (7413 ng/mL·h). t1/2 distribution and elimination (0.705 and 9.7 h, respectively), Cmax (1513 ng/mL), and Vd(ss) (1.71 L/kg). Mean values for the oral data included AUC (6243 ng/mL·h), t1/2 of absorption and elimination (0.227 and 8.19 h, respectively), and Cmax (480.0 ng/mL). Bioavailability of orally administered cyclosporine was 29 and 25% on days 7 and 14 respectively. Whole blood comment cyclosporine concentration 2 h after administration (C 2) better correlated with AUC on days 7 and 14 than trough plasma concentration (C12). The rate of oral cyclosporine absorption was less than expected and there was substantial individual variation. Therapeutic drug monitoring strategies for cyclosporine in cats should be re-evaluated.

Original languageEnglish (US)
Pages (from-to)349-354
Number of pages6
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume26
Issue number5
DOIs
StatePublished - Oct 2003

Fingerprint

cyclosporine
oral administration
Cyclosporine
Oral Administration
Cats
cats
dosage
Area Under Curve
mouth
Drug Monitoring
drugs
therapeutics
monitoring
blood
intravenous injection
Intravenous Administration
Biological Availability
pharmacokinetics
bioavailability
Pharmacokinetics

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

Cite this

Disposition of cyclosporine after intravenous and multi-dose oral administration in cats. / Mehl, M. L.; Kyles, A. E.; Craigmill, A. L.; Epstein, Steven E; Gregory, C. R.

In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 26, No. 5, 10.2003, p. 349-354.

Research output: Contribution to journalArticle

Mehl, M. L. ; Kyles, A. E. ; Craigmill, A. L. ; Epstein, Steven E ; Gregory, C. R. / Disposition of cyclosporine after intravenous and multi-dose oral administration in cats. In: Journal of Veterinary Pharmacology and Therapeutics. 2003 ; Vol. 26, No. 5. pp. 349-354.
@article{03820cfe0add43c6a42d5f6945b7dce8,
title = "Disposition of cyclosporine after intravenous and multi-dose oral administration in cats",
abstract = "The aim of this study was to evaluate the disposition of cyclosporine after intravenous (i.v.) and oral administration and to evaluate single sampling times for therapeutic monitoring of cyclosporine drug concentrations in cats. Six adult male cats (clinically intact) were used. Two treatments consisting of a single i.v. cyclosporine (1 mg/kg) and multiple oral cyclosporine (3 mg/kg b.i.d p.o. for 2 weeks) doses. Whole blood cyclosporine concentrations were measured at fixed times by high performance liquid chromatography and pharmacokinetic values were calculated. Mean values for the i.v. data included AUC (7413 ng/mL·h). t1/2 distribution and elimination (0.705 and 9.7 h, respectively), Cmax (1513 ng/mL), and Vd(ss) (1.71 L/kg). Mean values for the oral data included AUC (6243 ng/mL·h), t1/2 of absorption and elimination (0.227 and 8.19 h, respectively), and Cmax (480.0 ng/mL). Bioavailability of orally administered cyclosporine was 29 and 25{\%} on days 7 and 14 respectively. Whole blood comment cyclosporine concentration 2 h after administration (C 2) better correlated with AUC on days 7 and 14 than trough plasma concentration (C12). The rate of oral cyclosporine absorption was less than expected and there was substantial individual variation. Therapeutic drug monitoring strategies for cyclosporine in cats should be re-evaluated.",
author = "Mehl, {M. L.} and Kyles, {A. E.} and Craigmill, {A. L.} and Epstein, {Steven E} and Gregory, {C. R.}",
year = "2003",
month = "10",
doi = "10.1046/j.1365-2885.2003.00496.x",
language = "English (US)",
volume = "26",
pages = "349--354",
journal = "Journal of Veterinary Pharmacology and Therapeutics",
issn = "0140-7783",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Disposition of cyclosporine after intravenous and multi-dose oral administration in cats

AU - Mehl, M. L.

AU - Kyles, A. E.

AU - Craigmill, A. L.

AU - Epstein, Steven E

AU - Gregory, C. R.

PY - 2003/10

Y1 - 2003/10

N2 - The aim of this study was to evaluate the disposition of cyclosporine after intravenous (i.v.) and oral administration and to evaluate single sampling times for therapeutic monitoring of cyclosporine drug concentrations in cats. Six adult male cats (clinically intact) were used. Two treatments consisting of a single i.v. cyclosporine (1 mg/kg) and multiple oral cyclosporine (3 mg/kg b.i.d p.o. for 2 weeks) doses. Whole blood cyclosporine concentrations were measured at fixed times by high performance liquid chromatography and pharmacokinetic values were calculated. Mean values for the i.v. data included AUC (7413 ng/mL·h). t1/2 distribution and elimination (0.705 and 9.7 h, respectively), Cmax (1513 ng/mL), and Vd(ss) (1.71 L/kg). Mean values for the oral data included AUC (6243 ng/mL·h), t1/2 of absorption and elimination (0.227 and 8.19 h, respectively), and Cmax (480.0 ng/mL). Bioavailability of orally administered cyclosporine was 29 and 25% on days 7 and 14 respectively. Whole blood comment cyclosporine concentration 2 h after administration (C 2) better correlated with AUC on days 7 and 14 than trough plasma concentration (C12). The rate of oral cyclosporine absorption was less than expected and there was substantial individual variation. Therapeutic drug monitoring strategies for cyclosporine in cats should be re-evaluated.

AB - The aim of this study was to evaluate the disposition of cyclosporine after intravenous (i.v.) and oral administration and to evaluate single sampling times for therapeutic monitoring of cyclosporine drug concentrations in cats. Six adult male cats (clinically intact) were used. Two treatments consisting of a single i.v. cyclosporine (1 mg/kg) and multiple oral cyclosporine (3 mg/kg b.i.d p.o. for 2 weeks) doses. Whole blood cyclosporine concentrations were measured at fixed times by high performance liquid chromatography and pharmacokinetic values were calculated. Mean values for the i.v. data included AUC (7413 ng/mL·h). t1/2 distribution and elimination (0.705 and 9.7 h, respectively), Cmax (1513 ng/mL), and Vd(ss) (1.71 L/kg). Mean values for the oral data included AUC (6243 ng/mL·h), t1/2 of absorption and elimination (0.227 and 8.19 h, respectively), and Cmax (480.0 ng/mL). Bioavailability of orally administered cyclosporine was 29 and 25% on days 7 and 14 respectively. Whole blood comment cyclosporine concentration 2 h after administration (C 2) better correlated with AUC on days 7 and 14 than trough plasma concentration (C12). The rate of oral cyclosporine absorption was less than expected and there was substantial individual variation. Therapeutic drug monitoring strategies for cyclosporine in cats should be re-evaluated.

UR - http://www.scopus.com/inward/record.url?scp=0242551760&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242551760&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2885.2003.00496.x

DO - 10.1046/j.1365-2885.2003.00496.x

M3 - Article

C2 - 14633187

AN - SCOPUS:0242551760

VL - 26

SP - 349

EP - 354

JO - Journal of Veterinary Pharmacology and Therapeutics

JF - Journal of Veterinary Pharmacology and Therapeutics

SN - 0140-7783

IS - 5

ER -