Disposition and Analgesic Effects of Fentanyl in White Cockatoos (Cacatua alba)

Sharman Hoppes, Keven Flammer, Karen Hoersch, Mark Papich, Joanne R Paul-Murphy

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Fentanyl is a mu opioid agonist with 80-100 times the analgesic potency of morphine. Fentanyl is used in several mammalian species for relief of severe pain, but its use has not been investigated in psittacine birds. To determine the pharmacologic disposition of fentanyl in healthy white cockatoos (Cacatua alba), we measured fentanyl plasma concentrations in sequentially collected samples after administration of fentanyl at 0.01 or 0.02 mg/kg IM. To investigate the analgesic effects of fentanyl in conscious cockatoos, we compared the change in pre- and posttreatment levels of electrical and thermal noxious stimuli necessary to elicit a withdrawal response in birds administered fentanyl at 2 different doses (0.02 mg/kg IM or 0.2 mg/kg SC) and those given saline. Fentanyl was rapidly absorbed and plasma concentrations declined with an elimination half-life of 1.2-1.4 hours. Plasma concentrations considered to be analgesic in humans were maintained for at least 2 hours with the 0.02 mg/kg dose. However, no significant difference was found in analgesic response between birds given saline and those given fentanyl at 0.02 mg/kg IM. Although the 0.2 mg/kg SC dose provided significant analgesia in some birds, fentanyl at this dose is not recommended as a routine analgesic agent because a large volume of drug must be injected and this dose causes hyperactivity in some birds.

Original languageEnglish (US)
Pages (from-to)124-130
Number of pages7
JournalJournal of Avian Medicine and Surgery
Volume17
Issue number3
StatePublished - Sep 2003
Externally publishedYes

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Cockatoos
fentanyl
analgesic effect
Fentanyl
Analgesics
Birds
analgesics
birds
dosage
Psittaciformes
Cacatua
Cacatuidae
morphine
narcotics
analgesia
Analgesia
Morphine
Opioid Analgesics
agonists
half life

Keywords

  • Analgesia
  • Cacatua alba
  • Cockatoo
  • Fentanyl
  • Opioids
  • Pharmacokinetics
  • Psittaciformes

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Disposition and Analgesic Effects of Fentanyl in White Cockatoos (Cacatua alba). / Hoppes, Sharman; Flammer, Keven; Hoersch, Karen; Papich, Mark; Paul-Murphy, Joanne R.

In: Journal of Avian Medicine and Surgery, Vol. 17, No. 3, 09.2003, p. 124-130.

Research output: Contribution to journalArticle

Hoppes, Sharman ; Flammer, Keven ; Hoersch, Karen ; Papich, Mark ; Paul-Murphy, Joanne R. / Disposition and Analgesic Effects of Fentanyl in White Cockatoos (Cacatua alba). In: Journal of Avian Medicine and Surgery. 2003 ; Vol. 17, No. 3. pp. 124-130.
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