Disparities in survival after Hodgkin lymphoma: A population-based study

Theresa H Keegan, Christina A. Clarke, Ellen T. Chang, Sarah J. Shema, Sally L. Glaser

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Survival after Hodgkin lymphoma (HL) is generally favorable, but may vary by patient demographic characteristics. The authors examined HL survival according to race/ethnicity and neighborhood socioeconomic status (SES), determined from residential census-block group at diagnosis. For 12,492 classical HL patients ≥15 years diagnosed in California during 1988-2006 and followed through 2007, we determined risk of overall and HL-specific death using Cox proportional hazards regression; analyses were stratified by age and Ann Arbor stage. Irrespective of disease stage, patients with lower neighborhood SES had worse overall and HL-specific survival than patients with higher SES. Patients with the lowest quintile of neighborhood SES had a 64% (patients aged 15-44 years) and 36% (≥45 years) increased risk of HL-death compared to patients with the highest quintile of SES; SES results were similar for overall survival. Even after adjustment for neighborhood SES, blacks and Hispanics had increased risks of HL-death 74% and 43% (15-44 years) and 40% and 17% (≥45 years), respectively, higher than white patients. The racial/ethnic differences in survival were evident for all stages of disease. These data provide evidence for substantial, and probably remediable, racial/ethnic and neighborhood SES disparities in HL outcomes.

Original languageEnglish (US)
Pages (from-to)1881-1892
Number of pages12
JournalCancer Causes and Control
Volume20
Issue number10
DOIs
StatePublished - Dec 2009
Externally publishedYes

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Keywords

  • Census
  • Hodgkin disease
  • Mortality
  • Social class
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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