Disopyramide phosphate: Clinical efficacy of a new oral antiarrhythmic drug

Louis A. Vismara, Dean T. Mason, Ezra A Amsterdam

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Abstract

The efficacy o f disopyramide phosphate (DP), a new oral antiarrhythmic agent, was evaluated by serial ten hour, portable electrocardiographic monitoring during placebo (P) and DP administration. In this 16 week outpatient study, DP therapy reduced the frequency of all cardiac ectopic depolarizations (ED) in 10 of 17 patients (average occurrence: P 145 per hour and DP 4 per hour, p < 0.05). Further, ventricular arrhythmias (VA): ventricular tachycardia (VT), and complicated VED, were recorded during P in 8 of 17 and in 16 of 17 patients, respectively, but this prevalence diminished with DP administration (VT 1 of 17, p < 0.05; VED 10 of 17 patients, p < 0.05). Atrial tachycardia (AT), noted in 6 patients during P, was abolished in 4 during active drug treatment. Despite minor anticholinergic adverse effects in 6 patients, DP was well tolerated in 17 of 18 patients and appeared safe even in 5 patients with cardiac decompensation prior to its administration.

Original languageEnglish (US)
Pages (from-to)330-335
Number of pages6
JournalClinical Pharmacology and Therapeutics
Volume16
Issue number2
StatePublished - Aug 1974

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ASJC Scopus subject areas

  • Pharmacology

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