Abstract
Several clostridial species, including Clostridium perfringens, Clostridium difficile, and Clostridium spiroforme, affect the intestinal tract of rabbits. This chapter describes enteric disease produced by C. spiroforme, which is considered the most prevalent clostridial pathogen responsible for rabbit enteric disease, particularly in young animals. C. spiroforme is acquired by the fecal-oral route and colonizes the terminal small intestine and cecum, where it produces C. spiroforme toxin (CST), which is considered to be the main virulence factor of this microorganism. Antibiotic treatment should include narrow-spectrum orally administered antibiotics with activity against Gram-positive antibiotics; examples include penicillin and ampicillin, although macrolide and lincosamide activity is poor. Probiotics are frequently used in the treatment of gastrointestinal diseases of rabbits based largely on anecdotal evidence of a beneficial effect rather than on scientific study. Little work has been performed to understand the basis of immunity to C. spiroforme infection and develop effective immunization strategies.
| Original language | English (US) |
|---|---|
| Title of host publication | Clostridial Diseases in Animals |
| Publisher | wiley |
| Pages | 221-227 |
| Number of pages | 7 |
| ISBN (Electronic) | 9781118728291 |
| ISBN (Print) | 9781118728406 |
| DOIs | |
| State | Published - Apr 8 2016 |
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Keywords
- C. spiroforme toxin
- Clostridium spiroforme
- Enteric disease
- Gastrointestinal diseases
- Probiotics
- Rabbit
- Virulence factor
ASJC Scopus subject areas
- veterinary(all)
Cite this
Diseases Produced by Clostridium spiroforme. / Songer, J. Glenn; Uzal, Francisco A.
Clostridial Diseases in Animals. wiley, 2016. p. 221-227.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Diseases Produced by Clostridium spiroforme
AU - Songer, J. Glenn
AU - Uzal, Francisco A
PY - 2016/4/8
Y1 - 2016/4/8
N2 - Several clostridial species, including Clostridium perfringens, Clostridium difficile, and Clostridium spiroforme, affect the intestinal tract of rabbits. This chapter describes enteric disease produced by C. spiroforme, which is considered the most prevalent clostridial pathogen responsible for rabbit enteric disease, particularly in young animals. C. spiroforme is acquired by the fecal-oral route and colonizes the terminal small intestine and cecum, where it produces C. spiroforme toxin (CST), which is considered to be the main virulence factor of this microorganism. Antibiotic treatment should include narrow-spectrum orally administered antibiotics with activity against Gram-positive antibiotics; examples include penicillin and ampicillin, although macrolide and lincosamide activity is poor. Probiotics are frequently used in the treatment of gastrointestinal diseases of rabbits based largely on anecdotal evidence of a beneficial effect rather than on scientific study. Little work has been performed to understand the basis of immunity to C. spiroforme infection and develop effective immunization strategies.
AB - Several clostridial species, including Clostridium perfringens, Clostridium difficile, and Clostridium spiroforme, affect the intestinal tract of rabbits. This chapter describes enteric disease produced by C. spiroforme, which is considered the most prevalent clostridial pathogen responsible for rabbit enteric disease, particularly in young animals. C. spiroforme is acquired by the fecal-oral route and colonizes the terminal small intestine and cecum, where it produces C. spiroforme toxin (CST), which is considered to be the main virulence factor of this microorganism. Antibiotic treatment should include narrow-spectrum orally administered antibiotics with activity against Gram-positive antibiotics; examples include penicillin and ampicillin, although macrolide and lincosamide activity is poor. Probiotics are frequently used in the treatment of gastrointestinal diseases of rabbits based largely on anecdotal evidence of a beneficial effect rather than on scientific study. Little work has been performed to understand the basis of immunity to C. spiroforme infection and develop effective immunization strategies.
KW - C. spiroforme toxin
KW - Clostridium spiroforme
KW - Enteric disease
KW - Gastrointestinal diseases
KW - Probiotics
KW - Rabbit
KW - Virulence factor
UR - http://www.scopus.com/inward/record.url?scp=85024852928&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85024852928&partnerID=8YFLogxK
U2 - 10.1002/9781118728291.ch18
DO - 10.1002/9781118728291.ch18
M3 - Chapter
AN - SCOPUS:85024852928
SN - 9781118728406
SP - 221
EP - 227
BT - Clostridial Diseases in Animals
PB - wiley
ER -