Abstract
Enterotoxemia caused by Clostridium perfringens type D, sometimes also called overeating disease or pulpy kidney disease, is a prevalent clostridial disease of sheep and goats. This chapter discusses the etiology, epidemiology and pathogenesis, clinical signs, diagnosis, prophylaxis, and treatment of diseases produced by C. perfringens type D. Type D enterotoxemia in sheep is a pure enterotoxemia, with no bacterial invasion of tissues, whereas in goats it may be a pure enterotoxemia, a localized enteric disease, or a combination of both. C. perfringens type D produces two typing toxins, namely alpha (CPA) and epsilon (ETX), although most type D isolates may express several other toxins. In sheep, a presumptive clinical diagnosis can be based on a history of access to heavy grain or concentrate feeding or abundant lush pasture, and clinical signs, especially in unvaccinated thriving lambs. Immunity in sheep is readily produced by vaccination, most vaccines being alum-adsorbed ETX toxoid.
| Original language | English (US) |
|---|---|
| Title of host publication | Clostridial Diseases in Animals |
| Publisher | wiley |
| Pages | 157-172 |
| Number of pages | 16 |
| ISBN (Electronic) | 9781118728291 |
| ISBN (Print) | 9781118728406 |
| DOIs | |
| State | Published - Apr 8 2016 |
| Externally published | Yes |
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Keywords
- Adult goats
- Adult sheep
- Alpha toxin
- C. perfringens Type D
- Enterotoxemia
- Epsilon toxin
ASJC Scopus subject areas
- veterinary(all)
Cite this
Diseases Produced by Clostridium perfringens Type D. / Uzal, Francisco A; Giannitti, Federico; Finnie, John W.; García, Jorge P.
Clostridial Diseases in Animals. wiley, 2016. p. 157-172.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Diseases Produced by Clostridium perfringens Type D
AU - Uzal, Francisco A
AU - Giannitti, Federico
AU - Finnie, John W.
AU - García, Jorge P.
PY - 2016/4/8
Y1 - 2016/4/8
N2 - Enterotoxemia caused by Clostridium perfringens type D, sometimes also called overeating disease or pulpy kidney disease, is a prevalent clostridial disease of sheep and goats. This chapter discusses the etiology, epidemiology and pathogenesis, clinical signs, diagnosis, prophylaxis, and treatment of diseases produced by C. perfringens type D. Type D enterotoxemia in sheep is a pure enterotoxemia, with no bacterial invasion of tissues, whereas in goats it may be a pure enterotoxemia, a localized enteric disease, or a combination of both. C. perfringens type D produces two typing toxins, namely alpha (CPA) and epsilon (ETX), although most type D isolates may express several other toxins. In sheep, a presumptive clinical diagnosis can be based on a history of access to heavy grain or concentrate feeding or abundant lush pasture, and clinical signs, especially in unvaccinated thriving lambs. Immunity in sheep is readily produced by vaccination, most vaccines being alum-adsorbed ETX toxoid.
AB - Enterotoxemia caused by Clostridium perfringens type D, sometimes also called overeating disease or pulpy kidney disease, is a prevalent clostridial disease of sheep and goats. This chapter discusses the etiology, epidemiology and pathogenesis, clinical signs, diagnosis, prophylaxis, and treatment of diseases produced by C. perfringens type D. Type D enterotoxemia in sheep is a pure enterotoxemia, with no bacterial invasion of tissues, whereas in goats it may be a pure enterotoxemia, a localized enteric disease, or a combination of both. C. perfringens type D produces two typing toxins, namely alpha (CPA) and epsilon (ETX), although most type D isolates may express several other toxins. In sheep, a presumptive clinical diagnosis can be based on a history of access to heavy grain or concentrate feeding or abundant lush pasture, and clinical signs, especially in unvaccinated thriving lambs. Immunity in sheep is readily produced by vaccination, most vaccines being alum-adsorbed ETX toxoid.
KW - Adult goats
KW - Adult sheep
KW - Alpha toxin
KW - C. perfringens Type D
KW - Enterotoxemia
KW - Epsilon toxin
UR - http://www.scopus.com/inward/record.url?scp=84991986955&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84991986955&partnerID=8YFLogxK
U2 - 10.1002/9781118728291.ch13
DO - 10.1002/9781118728291.ch13
M3 - Chapter
AN - SCOPUS:84991986955
SN - 9781118728406
SP - 157
EP - 172
BT - Clostridial Diseases in Animals
PB - wiley
ER -