Diseases Produced by Clostridium perfringens Type C

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Intestinal infection by Clostridium perfringens Type C causes necrotizing enteritis or enterocolitis in domestic animals and humans. In humans, type C disease is also known as enteritis necroticans, pigbel, or darmbrand. The disease has been reproduced experimentally in pigs, sheep, calves, and goats, while rabbits, and mice, and guinea pigs have been used in experimental models to study diverse aspects of the pathogenesis of type C disease. This chapter discusses the etiology, epidemiology, pathogenesis, clinical signs, prophylaxis, and treatment of diseases produced by C. perfringens Type C. The characteristic microscopic lesion of natural disease in all species is severe necrotizing and hemorrhagic enteritis or colitis with mucosal or submucosal thrombosis. C. perfringens vaccines for veterinary use are mostly prepared from semi-purified supernatants of cultures of C. perfringens types A, B, C, and D, or a combination of these types.

Original languageEnglish (US)
Title of host publicationClostridial Diseases in Animals
Number of pages13
ISBN (Electronic)9781118728291
ISBN (Print)9781118728406
StatePublished - Apr 8 2016


  • C. perfringens Type C
  • Hemorrhagic enteritis
  • Necrotizing enteritis
  • Submucosal thrombosis

ASJC Scopus subject areas

  • veterinary(all)


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