Disease Associated with Equine Coronavirus Infection and High Case Fatality Rate

C. L. Fielding, J. K. Higgins, J. C. Higgins, S. Mcintosh, E. Scott, F. Giannitti, Asli Mete, Nicola Pusterla

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Equine coronavirus (ECoV) is associated with clinical disease in adult horses. Outbreaks are associated with a low case fatality rate and a small number of animals with signs of encephalopathic disease are described. Objectives: The aim of this study is to describe the epidemiological and clinical features of two outbreaks of ECoV infection that were associated with an high case fatality rate. Animals: 14 miniature horses and 1 miniature donkey testing fecal positive for ECoV from two related disease outbreaks. Methods: Retrospective study describing the epidemiological findings, clinicopathological findings, and fecal viral load from affected horses. Results: In EcoV positive horses, 27% (4/15) of the animals died or were euthanized. Severe hyperammonemia (677 μmol/L, reference range ≤60 μmol/L) was identified in one animal with signs of encephalopathic disease that subsequently died. Fecal viral load (ECoV genome equivalents per gram of feces) was significantly higher in the nonsurvivors compared to animals that survived (P = .02). Conclusions and Clinical Importance: Equine coronavirus had a higher case fatality rate in this group of miniature horses than previously reported in other outbreaks of varying breeds. Hyperammonemia could contribute to signs of encephalopathic disease, and the fecal viral load might be of prognostic value in affected horses.

Original languageEnglish (US)
Pages (from-to)307-310
Number of pages4
JournalJournal of Veterinary Internal Medicine
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Coronavirus Infections
Coronavirinae
Horses
horses
Mortality
infection
Coronavirus
Disease Outbreaks
viral load
Viral Load
Hyperammonemia
animals
Equidae
asses
retrospective studies
Feces
Reference Values

Keywords

  • Ammonia
  • Encephalopathy
  • Enteritis
  • Infectious disease
  • Miniature horse

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Fielding, C. L., Higgins, J. K., Higgins, J. C., Mcintosh, S., Scott, E., Giannitti, F., ... Pusterla, N. (2015). Disease Associated with Equine Coronavirus Infection and High Case Fatality Rate. Journal of Veterinary Internal Medicine, 29(1), 307-310. https://doi.org/10.1111/jvim.12480

Disease Associated with Equine Coronavirus Infection and High Case Fatality Rate. / Fielding, C. L.; Higgins, J. K.; Higgins, J. C.; Mcintosh, S.; Scott, E.; Giannitti, F.; Mete, Asli; Pusterla, Nicola.

In: Journal of Veterinary Internal Medicine, Vol. 29, No. 1, 01.01.2015, p. 307-310.

Research output: Contribution to journalArticle

Fielding CL, Higgins JK, Higgins JC, Mcintosh S, Scott E, Giannitti F et al. Disease Associated with Equine Coronavirus Infection and High Case Fatality Rate. Journal of Veterinary Internal Medicine. 2015 Jan 1;29(1):307-310. https://doi.org/10.1111/jvim.12480
Fielding, C. L. ; Higgins, J. K. ; Higgins, J. C. ; Mcintosh, S. ; Scott, E. ; Giannitti, F. ; Mete, Asli ; Pusterla, Nicola. / Disease Associated with Equine Coronavirus Infection and High Case Fatality Rate. In: Journal of Veterinary Internal Medicine. 2015 ; Vol. 29, No. 1. pp. 307-310.
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