Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics.

Fan Yang, Ruiwu Liu, Randall Kramer, Wenwu Xiao, Richard Jordan, Kit S. Lam

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Oral squamous cell carcinoma has a low five-year survival rate, which may be due to late detection and a lack of effective tumor-specific therapies. Using a high throughput drug discovery strategy termed one-bead one-compound combinatorial library, the authors identified six compounds with high binding affinity to different human oral squamous cell carcinoma cell lines but not to normal cells. Current work is under way to develop these ligands to oral squamous cell carcinoma specific imaging probes or therapeutic agents.

Original languageEnglish (US)
Pages (from-to)939-943
Number of pages5
JournalJournal of the California Dental Association
Volume40
Issue number12
StatePublished - Dec 2012

Fingerprint

Squamous Cell Carcinoma
Ligands
Pharmaceutical Preparations
Neoplasms
Drug Discovery
Cell Line
Therapeutics

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics. / Yang, Fan; Liu, Ruiwu; Kramer, Randall; Xiao, Wenwu; Jordan, Richard; Lam, Kit S.

In: Journal of the California Dental Association, Vol. 40, No. 12, 12.2012, p. 939-943.

Research output: Contribution to journalArticle

@article{2fbc71f741a944d086bbe1908a267012,
title = "Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics.",
abstract = "Oral squamous cell carcinoma has a low five-year survival rate, which may be due to late detection and a lack of effective tumor-specific therapies. Using a high throughput drug discovery strategy termed one-bead one-compound combinatorial library, the authors identified six compounds with high binding affinity to different human oral squamous cell carcinoma cell lines but not to normal cells. Current work is under way to develop these ligands to oral squamous cell carcinoma specific imaging probes or therapeutic agents.",
author = "Fan Yang and Ruiwu Liu and Randall Kramer and Wenwu Xiao and Richard Jordan and Lam, {Kit S.}",
year = "2012",
month = "12",
language = "English (US)",
volume = "40",
pages = "939--943",
journal = "CDA journal California Dental Association",
issn = "1043-2256",
publisher = "California Dental Association",
number = "12",

}

TY - JOUR

T1 - Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics.

AU - Yang, Fan

AU - Liu, Ruiwu

AU - Kramer, Randall

AU - Xiao, Wenwu

AU - Jordan, Richard

AU - Lam, Kit S.

PY - 2012/12

Y1 - 2012/12

N2 - Oral squamous cell carcinoma has a low five-year survival rate, which may be due to late detection and a lack of effective tumor-specific therapies. Using a high throughput drug discovery strategy termed one-bead one-compound combinatorial library, the authors identified six compounds with high binding affinity to different human oral squamous cell carcinoma cell lines but not to normal cells. Current work is under way to develop these ligands to oral squamous cell carcinoma specific imaging probes or therapeutic agents.

AB - Oral squamous cell carcinoma has a low five-year survival rate, which may be due to late detection and a lack of effective tumor-specific therapies. Using a high throughput drug discovery strategy termed one-bead one-compound combinatorial library, the authors identified six compounds with high binding affinity to different human oral squamous cell carcinoma cell lines but not to normal cells. Current work is under way to develop these ligands to oral squamous cell carcinoma specific imaging probes or therapeutic agents.

UR - http://www.scopus.com/inward/record.url?scp=84874795895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874795895&partnerID=8YFLogxK

M3 - Article

C2 - 23362666

AN - SCOPUS:84874795895

VL - 40

SP - 939

EP - 943

JO - CDA journal California Dental Association

JF - CDA journal California Dental Association

SN - 1043-2256

IS - 12

ER -