Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics.

Fan Yang, Ruiwu Liu, Randall Kramer, Wenwu Xiao, Richard Jordan, Kit S. Lam

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Oral squamous cell carcinoma has a low five-year survival rate, which may be due to late detection and a lack of effective tumor-specific therapies. Using a high throughput drug discovery strategy termed one-bead one-compound combinatorial library, the authors identified six compounds with high binding affinity to different human oral squamous cell carcinoma cell lines but not to normal cells. Current work is under way to develop these ligands to oral squamous cell carcinoma specific imaging probes or therapeutic agents.

Original languageEnglish (US)
Pages (from-to)939-943
Number of pages5
JournalJournal of the California Dental Association
Volume40
Issue number12
StatePublished - Dec 2012

ASJC Scopus subject areas

  • Dentistry(all)

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