Abstract
Oral squamous cell carcinoma has a low five-year survival rate, which may be due to late detection and a lack of effective tumor-specific therapies. Using a high throughput drug discovery strategy termed one-bead one-compound combinatorial library, the authors identified six compounds with high binding affinity to different human oral squamous cell carcinoma cell lines but not to normal cells. Current work is under way to develop these ligands to oral squamous cell carcinoma specific imaging probes or therapeutic agents.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 939-943 |
| Number of pages | 5 |
| Journal | Journal of the California Dental Association |
| Volume | 40 |
| Issue number | 12 |
| State | Published - Dec 2012 |
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ASJC Scopus subject areas
- Dentistry(all)
Cite this
Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics. / Yang, Fan; Liu, Ruiwu; Kramer, Randall; Xiao, Wenwu; Jordan, Richard; Lam, Kit S.
In: Journal of the California Dental Association, Vol. 40, No. 12, 12.2012, p. 939-943.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics.
AU - Yang, Fan
AU - Liu, Ruiwu
AU - Kramer, Randall
AU - Xiao, Wenwu
AU - Jordan, Richard
AU - Lam, Kit S.
PY - 2012/12
Y1 - 2012/12
N2 - Oral squamous cell carcinoma has a low five-year survival rate, which may be due to late detection and a lack of effective tumor-specific therapies. Using a high throughput drug discovery strategy termed one-bead one-compound combinatorial library, the authors identified six compounds with high binding affinity to different human oral squamous cell carcinoma cell lines but not to normal cells. Current work is under way to develop these ligands to oral squamous cell carcinoma specific imaging probes or therapeutic agents.
AB - Oral squamous cell carcinoma has a low five-year survival rate, which may be due to late detection and a lack of effective tumor-specific therapies. Using a high throughput drug discovery strategy termed one-bead one-compound combinatorial library, the authors identified six compounds with high binding affinity to different human oral squamous cell carcinoma cell lines but not to normal cells. Current work is under way to develop these ligands to oral squamous cell carcinoma specific imaging probes or therapeutic agents.
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UR - http://www.scopus.com/inward/citedby.url?scp=84874795895&partnerID=8YFLogxK
M3 - Article
C2 - 23362666
AN - SCOPUS:84874795895
VL - 40
SP - 939
EP - 943
JO - CDA journal California Dental Association
JF - CDA journal California Dental Association
SN - 1043-2256
IS - 12
ER -