Discovery of bone morphogenetic proteins – A historical perspective

T. Kuber Sampath, A. Hari Reddi

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Bone morphogenetic proteins (BMPs) were purified from demineralized bone matrix by their ability to induce new bone formation in vivo. BMPs represent a large sub-family of proteins structurally related to TGF-beta and activins. Two BMP bone graft substitutes, BMP2 (InFuse®) and BMP7 (OP1®) have been developed as products for the repair of long bone non-union fractures and lumbar spinal fusion in humans. The approval of BMP2 and BMP7 based products for use in the clinic supports that the signals responsible for bone formation at ectopic sites can form a basis as therapeutics for bone repair and regeneration. This article describes a historical perspective of the discovery BMPs.

Original languageEnglish (US)
Article number115548
JournalBone
Volume140
DOIs
StatePublished - Nov 2020

Keywords

  • BMP
  • Bone repair
  • Review

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

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