Discovery of a novel hepatovirus (Phopivirus of seals) related to human hepatitis A virus

S. J. Anthony, J. A.S. Leger, E. Liang, A. L. Hicks, M. D. Sanchez Leon, K. Jain, J. H. Lefkowitch, I. Navarrete-Macias, N. Knowles, Tracey Goldstein, K. Pugliares, H. S. Ip, T. Rowles, W. I. Lipkin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Describing the viral diversity of wildlife can provide interesting and useful insights into the natural history of established human pathogens. In this study, we describe a previously unknown picornavirus in harbor seals (tentatively named phopivirus) that is related to human hepatitis A virus (HAV). We show that phopivirus shares several genetic and phenotypic characteristics with HAV, including phylogenetic relatedness across the genome, a specific and seemingly quiescent tropism for hepatocytes, structural conservation in a key functional region of the type III internal ribosomal entry site (IRES), and a codon usage bias consistent with that of HAV. IMPORTANCE Hepatitis A virus (HAV) is an important viral hepatitis in humans because of the substantial number of cases each year in regions with low socioeconomic status. The origin of HAV is unknown, and no nonprimate HAV-like viruses have been described. Here, we describe the discovery of an HAV-like virus in seals. This finding suggests that the diversity and evolutionary history of these viruses might be far greater than previously thought and may provide insight into the origin and pathogenicity of HAV.

Original languageEnglish (US)
Article numbere01180-15
JournalmBio
Volume6
Issue number4
DOIs
StatePublished - Aug 25 2015

Fingerprint

Human hepatitis A virus
Hepatovirus
Hepatitis A virus
Viruses
Hepatitis, Viral, Human
Phoca
Picornaviridae
Tropism
Natural History
Social Class
Codon
Virulence
Hepatocytes
Genome

ASJC Scopus subject areas

  • Microbiology
  • Virology

Cite this

Anthony, S. J., Leger, J. A. S., Liang, E., Hicks, A. L., Sanchez Leon, M. D., Jain, K., ... Lipkin, W. I. (2015). Discovery of a novel hepatovirus (Phopivirus of seals) related to human hepatitis A virus. mBio, 6(4), [e01180-15]. https://doi.org/10.1128/mBio.01180-15

Discovery of a novel hepatovirus (Phopivirus of seals) related to human hepatitis A virus. / Anthony, S. J.; Leger, J. A.S.; Liang, E.; Hicks, A. L.; Sanchez Leon, M. D.; Jain, K.; Lefkowitch, J. H.; Navarrete-Macias, I.; Knowles, N.; Goldstein, Tracey; Pugliares, K.; Ip, H. S.; Rowles, T.; Lipkin, W. I.

In: mBio, Vol. 6, No. 4, e01180-15, 25.08.2015.

Research output: Contribution to journalArticle

Anthony, SJ, Leger, JAS, Liang, E, Hicks, AL, Sanchez Leon, MD, Jain, K, Lefkowitch, JH, Navarrete-Macias, I, Knowles, N, Goldstein, T, Pugliares, K, Ip, HS, Rowles, T & Lipkin, WI 2015, 'Discovery of a novel hepatovirus (Phopivirus of seals) related to human hepatitis A virus', mBio, vol. 6, no. 4, e01180-15. https://doi.org/10.1128/mBio.01180-15
Anthony SJ, Leger JAS, Liang E, Hicks AL, Sanchez Leon MD, Jain K et al. Discovery of a novel hepatovirus (Phopivirus of seals) related to human hepatitis A virus. mBio. 2015 Aug 25;6(4). e01180-15. https://doi.org/10.1128/mBio.01180-15
Anthony, S. J. ; Leger, J. A.S. ; Liang, E. ; Hicks, A. L. ; Sanchez Leon, M. D. ; Jain, K. ; Lefkowitch, J. H. ; Navarrete-Macias, I. ; Knowles, N. ; Goldstein, Tracey ; Pugliares, K. ; Ip, H. S. ; Rowles, T. ; Lipkin, W. I. / Discovery of a novel hepatovirus (Phopivirus of seals) related to human hepatitis A virus. In: mBio. 2015 ; Vol. 6, No. 4.
@article{557a3a9ed0b64eb58bda705f381d789f,
title = "Discovery of a novel hepatovirus (Phopivirus of seals) related to human hepatitis A virus",
abstract = "Describing the viral diversity of wildlife can provide interesting and useful insights into the natural history of established human pathogens. In this study, we describe a previously unknown picornavirus in harbor seals (tentatively named phopivirus) that is related to human hepatitis A virus (HAV). We show that phopivirus shares several genetic and phenotypic characteristics with HAV, including phylogenetic relatedness across the genome, a specific and seemingly quiescent tropism for hepatocytes, structural conservation in a key functional region of the type III internal ribosomal entry site (IRES), and a codon usage bias consistent with that of HAV. IMPORTANCE Hepatitis A virus (HAV) is an important viral hepatitis in humans because of the substantial number of cases each year in regions with low socioeconomic status. The origin of HAV is unknown, and no nonprimate HAV-like viruses have been described. Here, we describe the discovery of an HAV-like virus in seals. This finding suggests that the diversity and evolutionary history of these viruses might be far greater than previously thought and may provide insight into the origin and pathogenicity of HAV.",
author = "Anthony, {S. J.} and Leger, {J. A.S.} and E. Liang and Hicks, {A. L.} and {Sanchez Leon}, {M. D.} and K. Jain and Lefkowitch, {J. H.} and I. Navarrete-Macias and N. Knowles and Tracey Goldstein and K. Pugliares and Ip, {H. S.} and T. Rowles and Lipkin, {W. I.}",
year = "2015",
month = "8",
day = "25",
doi = "10.1128/mBio.01180-15",
language = "English (US)",
volume = "6",
journal = "mBio",
issn = "2161-2129",
publisher = "American Society for Microbiology",
number = "4",

}

TY - JOUR

T1 - Discovery of a novel hepatovirus (Phopivirus of seals) related to human hepatitis A virus

AU - Anthony, S. J.

AU - Leger, J. A.S.

AU - Liang, E.

AU - Hicks, A. L.

AU - Sanchez Leon, M. D.

AU - Jain, K.

AU - Lefkowitch, J. H.

AU - Navarrete-Macias, I.

AU - Knowles, N.

AU - Goldstein, Tracey

AU - Pugliares, K.

AU - Ip, H. S.

AU - Rowles, T.

AU - Lipkin, W. I.

PY - 2015/8/25

Y1 - 2015/8/25

N2 - Describing the viral diversity of wildlife can provide interesting and useful insights into the natural history of established human pathogens. In this study, we describe a previously unknown picornavirus in harbor seals (tentatively named phopivirus) that is related to human hepatitis A virus (HAV). We show that phopivirus shares several genetic and phenotypic characteristics with HAV, including phylogenetic relatedness across the genome, a specific and seemingly quiescent tropism for hepatocytes, structural conservation in a key functional region of the type III internal ribosomal entry site (IRES), and a codon usage bias consistent with that of HAV. IMPORTANCE Hepatitis A virus (HAV) is an important viral hepatitis in humans because of the substantial number of cases each year in regions with low socioeconomic status. The origin of HAV is unknown, and no nonprimate HAV-like viruses have been described. Here, we describe the discovery of an HAV-like virus in seals. This finding suggests that the diversity and evolutionary history of these viruses might be far greater than previously thought and may provide insight into the origin and pathogenicity of HAV.

AB - Describing the viral diversity of wildlife can provide interesting and useful insights into the natural history of established human pathogens. In this study, we describe a previously unknown picornavirus in harbor seals (tentatively named phopivirus) that is related to human hepatitis A virus (HAV). We show that phopivirus shares several genetic and phenotypic characteristics with HAV, including phylogenetic relatedness across the genome, a specific and seemingly quiescent tropism for hepatocytes, structural conservation in a key functional region of the type III internal ribosomal entry site (IRES), and a codon usage bias consistent with that of HAV. IMPORTANCE Hepatitis A virus (HAV) is an important viral hepatitis in humans because of the substantial number of cases each year in regions with low socioeconomic status. The origin of HAV is unknown, and no nonprimate HAV-like viruses have been described. Here, we describe the discovery of an HAV-like virus in seals. This finding suggests that the diversity and evolutionary history of these viruses might be far greater than previously thought and may provide insight into the origin and pathogenicity of HAV.

UR - http://www.scopus.com/inward/record.url?scp=84940840655&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940840655&partnerID=8YFLogxK

U2 - 10.1128/mBio.01180-15

DO - 10.1128/mBio.01180-15

M3 - Article

C2 - 26307166

AN - SCOPUS:84940840655

VL - 6

JO - mBio

JF - mBio

SN - 2161-2129

IS - 4

M1 - e01180-15

ER -