Discovering the truth about life after discharge

Long-term trauma-related mortality

Rachael A. Callcut, Glenn Wakam, Amanda S. Conroy, Lucy Z. Kornblith, Benjamin M. Howard, Eric M. Campion, Mary F. Nelson, Matthew Mell, Mitchell J. Cohen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background Outcome after traumatic injury has typically been limited to the determination at time of discharge or brief follow-up. This study investigates the natural history of long-term survival after trauma. Methods All highest-level activation patients prospectively enrolled in an ongoing cohort study from 2005 to 2012 were selected. To allow for long-term follow-up, patients had to be enrolled at least 1 year before the latest available data from the National Death Index (NDI, 2013). Time and cause of mortality was determined based on death certificates. Survival status was determined by the latest date of either care in our institution or NDI query. Kaplan-Meier curves were created stratified for Injury Severity Score (ISS). Survival was compared with estimated actuarial survival based on age, sex, and race. Results A total of 908 highest-level activation patients (median ISS, 18) were followed up for a median 1.7 years (interquartile range 1.0-2.9; maximum, 9.8 years). Survival data were available on 99.8%. Overall survival was 73% (663 of 908). For those with at least 2-year follow-up, survival was only 62% (317 of 509). Severity of injury predicted long-term survival (p < 0.0001) with those having ISS of 25 or greater with the poorest outcome (57% survival at 5 years). For all ISS groups, survival was worse than predicted actuarial survival (p < 0.001). When excluding early deaths (≤30 days), observed survival was still significantly lower than estimated actuarial survival (p < 0.002). Eighteen percent (44 of 245 deaths) of all deaths occurred after 30 days. Among late deaths, 53% occurred between 31 days and 1 year after trauma. Trauma-related mortality was the leading cause of postdischarge death, accounting for 43% of the late deaths. Conclusion Postdischarge deaths represent a significant percentage of total trauma-related mortality. Despite having "survived" to leave the hospital, long-term survival was worse than predicted actuarial survival, suggesting that the mortality from injury does not end at "successful" hospital discharge. Level of Evidence Prognostic study, level III.

Original languageEnglish (US)
Pages (from-to)210-217
Number of pages8
JournalJournal of Trauma and Acute Care Surgery
Volume80
Issue number2
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

Fingerprint

Survival
Mortality
Wounds and Injuries
Injury Severity Score
Death Certificates
Natural History
Cause of Death
Cohort Studies

Keywords

  • long-term death
  • postdischarge outcome
  • trauma
  • Trauma-related mortality

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

Cite this

Callcut, R. A., Wakam, G., Conroy, A. S., Kornblith, L. Z., Howard, B. M., Campion, E. M., ... Cohen, M. J. (2016). Discovering the truth about life after discharge: Long-term trauma-related mortality. Journal of Trauma and Acute Care Surgery, 80(2), 210-217. https://doi.org/10.1097/TA.0000000000000930

Discovering the truth about life after discharge : Long-term trauma-related mortality. / Callcut, Rachael A.; Wakam, Glenn; Conroy, Amanda S.; Kornblith, Lucy Z.; Howard, Benjamin M.; Campion, Eric M.; Nelson, Mary F.; Mell, Matthew; Cohen, Mitchell J.

In: Journal of Trauma and Acute Care Surgery, Vol. 80, No. 2, 01.02.2016, p. 210-217.

Research output: Contribution to journalArticle

Callcut, RA, Wakam, G, Conroy, AS, Kornblith, LZ, Howard, BM, Campion, EM, Nelson, MF, Mell, M & Cohen, MJ 2016, 'Discovering the truth about life after discharge: Long-term trauma-related mortality', Journal of Trauma and Acute Care Surgery, vol. 80, no. 2, pp. 210-217. https://doi.org/10.1097/TA.0000000000000930
Callcut, Rachael A. ; Wakam, Glenn ; Conroy, Amanda S. ; Kornblith, Lucy Z. ; Howard, Benjamin M. ; Campion, Eric M. ; Nelson, Mary F. ; Mell, Matthew ; Cohen, Mitchell J. / Discovering the truth about life after discharge : Long-term trauma-related mortality. In: Journal of Trauma and Acute Care Surgery. 2016 ; Vol. 80, No. 2. pp. 210-217.
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abstract = "Background Outcome after traumatic injury has typically been limited to the determination at time of discharge or brief follow-up. This study investigates the natural history of long-term survival after trauma. Methods All highest-level activation patients prospectively enrolled in an ongoing cohort study from 2005 to 2012 were selected. To allow for long-term follow-up, patients had to be enrolled at least 1 year before the latest available data from the National Death Index (NDI, 2013). Time and cause of mortality was determined based on death certificates. Survival status was determined by the latest date of either care in our institution or NDI query. Kaplan-Meier curves were created stratified for Injury Severity Score (ISS). Survival was compared with estimated actuarial survival based on age, sex, and race. Results A total of 908 highest-level activation patients (median ISS, 18) were followed up for a median 1.7 years (interquartile range 1.0-2.9; maximum, 9.8 years). Survival data were available on 99.8{\%}. Overall survival was 73{\%} (663 of 908). For those with at least 2-year follow-up, survival was only 62{\%} (317 of 509). Severity of injury predicted long-term survival (p < 0.0001) with those having ISS of 25 or greater with the poorest outcome (57{\%} survival at 5 years). For all ISS groups, survival was worse than predicted actuarial survival (p < 0.001). When excluding early deaths (≤30 days), observed survival was still significantly lower than estimated actuarial survival (p < 0.002). Eighteen percent (44 of 245 deaths) of all deaths occurred after 30 days. Among late deaths, 53{\%} occurred between 31 days and 1 year after trauma. Trauma-related mortality was the leading cause of postdischarge death, accounting for 43{\%} of the late deaths. Conclusion Postdischarge deaths represent a significant percentage of total trauma-related mortality. Despite having {"}survived{"} to leave the hospital, long-term survival was worse than predicted actuarial survival, suggesting that the mortality from injury does not end at {"}successful{"} hospital discharge. Level of Evidence Prognostic study, level III.",
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N2 - Background Outcome after traumatic injury has typically been limited to the determination at time of discharge or brief follow-up. This study investigates the natural history of long-term survival after trauma. Methods All highest-level activation patients prospectively enrolled in an ongoing cohort study from 2005 to 2012 were selected. To allow for long-term follow-up, patients had to be enrolled at least 1 year before the latest available data from the National Death Index (NDI, 2013). Time and cause of mortality was determined based on death certificates. Survival status was determined by the latest date of either care in our institution or NDI query. Kaplan-Meier curves were created stratified for Injury Severity Score (ISS). Survival was compared with estimated actuarial survival based on age, sex, and race. Results A total of 908 highest-level activation patients (median ISS, 18) were followed up for a median 1.7 years (interquartile range 1.0-2.9; maximum, 9.8 years). Survival data were available on 99.8%. Overall survival was 73% (663 of 908). For those with at least 2-year follow-up, survival was only 62% (317 of 509). Severity of injury predicted long-term survival (p < 0.0001) with those having ISS of 25 or greater with the poorest outcome (57% survival at 5 years). For all ISS groups, survival was worse than predicted actuarial survival (p < 0.001). When excluding early deaths (≤30 days), observed survival was still significantly lower than estimated actuarial survival (p < 0.002). Eighteen percent (44 of 245 deaths) of all deaths occurred after 30 days. Among late deaths, 53% occurred between 31 days and 1 year after trauma. Trauma-related mortality was the leading cause of postdischarge death, accounting for 43% of the late deaths. Conclusion Postdischarge deaths represent a significant percentage of total trauma-related mortality. Despite having "survived" to leave the hospital, long-term survival was worse than predicted actuarial survival, suggesting that the mortality from injury does not end at "successful" hospital discharge. Level of Evidence Prognostic study, level III.

AB - Background Outcome after traumatic injury has typically been limited to the determination at time of discharge or brief follow-up. This study investigates the natural history of long-term survival after trauma. Methods All highest-level activation patients prospectively enrolled in an ongoing cohort study from 2005 to 2012 were selected. To allow for long-term follow-up, patients had to be enrolled at least 1 year before the latest available data from the National Death Index (NDI, 2013). Time and cause of mortality was determined based on death certificates. Survival status was determined by the latest date of either care in our institution or NDI query. Kaplan-Meier curves were created stratified for Injury Severity Score (ISS). Survival was compared with estimated actuarial survival based on age, sex, and race. Results A total of 908 highest-level activation patients (median ISS, 18) were followed up for a median 1.7 years (interquartile range 1.0-2.9; maximum, 9.8 years). Survival data were available on 99.8%. Overall survival was 73% (663 of 908). For those with at least 2-year follow-up, survival was only 62% (317 of 509). Severity of injury predicted long-term survival (p < 0.0001) with those having ISS of 25 or greater with the poorest outcome (57% survival at 5 years). For all ISS groups, survival was worse than predicted actuarial survival (p < 0.001). When excluding early deaths (≤30 days), observed survival was still significantly lower than estimated actuarial survival (p < 0.002). Eighteen percent (44 of 245 deaths) of all deaths occurred after 30 days. Among late deaths, 53% occurred between 31 days and 1 year after trauma. Trauma-related mortality was the leading cause of postdischarge death, accounting for 43% of the late deaths. Conclusion Postdischarge deaths represent a significant percentage of total trauma-related mortality. Despite having "survived" to leave the hospital, long-term survival was worse than predicted actuarial survival, suggesting that the mortality from injury does not end at "successful" hospital discharge. Level of Evidence Prognostic study, level III.

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