Disappearance of AML1-MTG8 (ETO) fusion transcript in acute myeloid leukaemia patients with t(8;21) in long-term remission

Noriko Satake, N. Maseki, T. Kozu, A. Sakashita, H. Kobayashi, M. Sakurai, M. Ohki, Y. Kaneko

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

In a study of 23 patients with t(8;21)-associated acute myeloid leukaemia the AML1-MTG8 fusion transcript was present in the majority of serial samples obtained from 17 patients followed for up to 34 months after diagnosis, but was absent in samples from all six patients who had been in continuous complete remission for 61 months after allogeneic bone marrow transplantation (BMT), or for 52, 53, 123, 182 and 198 months, respectively, after courses of intensive chemotherapy. Previous studies showed that the AML1-MTG8 fusion transcript was present in most patients with this type of translocation in long-term remission. Our results indicate that blood cells of patients with t(8;21) in remission of over 10 years may not show the AML1-MTG8 fusion transcript, and that those of patients who have undergone allogeneic BMT or intensive chemotherapy may become fusion transcript-negative much earlier. Our study suggests that leukaemic cells with the AML1-MTG8 fusion transcript may survive for some time after courses of chemotherapy or BMT, but that they may eventually be eradicated by immunologic and other antileukaemic mechanisms.

Original languageEnglish (US)
Pages (from-to)892-898
Number of pages7
JournalBritish Journal of Haematology
Volume91
Issue number4
StatePublished - 1995
Externally publishedYes

Keywords

  • AML1-MTG8 fusion transcript
  • Long-term survivor
  • Minimal residual disease
  • Reverse transcription-polymerase chain reaction
  • T(8;21)-associated acute myeloid leukaemia

ASJC Scopus subject areas

  • Hematology

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    Satake, N., Maseki, N., Kozu, T., Sakashita, A., Kobayashi, H., Sakurai, M., Ohki, M., & Kaneko, Y. (1995). Disappearance of AML1-MTG8 (ETO) fusion transcript in acute myeloid leukaemia patients with t(8;21) in long-term remission. British Journal of Haematology, 91(4), 892-898.