Disaccharides as sialic acid aldolase substrates: Synthesis of disaccharides containing a sialic acid at the reducing end

Shengshu Huang, Hai Yu, Xi Chen

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

(Chemical Equation Presented) Synthesis with an unfussy enzyme: Escherichia coli sialic acid aldolase has been found to be unusually flexible in accepting disaccharides containing a mannose (Man) or N-glycolylmannosamine (ManNGc) at the reducing end as substrates for synthesizing disaccharides containing deaminoneuraminic acid (KDN)or N-glycolylneuraminic acid (Neu5Gc) at the reducing end (see scheme; Gal: galactose; Glc: glucose). The chemoenzymatic method is general and efficient.

Original languageEnglish (US)
Pages (from-to)2249-2253
Number of pages5
JournalAngewandte Chemie - International Edition
Volume46
Issue number13
DOIs
StatePublished - 2007

Keywords

  • Aldolases
  • Carbohydrates
  • Chemoenzymatic synthesis
  • Enzyme catalysis
  • Sialic acids

ASJC Scopus subject areas

  • Chemistry(all)

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