Abstract
Background.The purpose of this study is to examine whether physical disability is associated with faster rate of decline in cognitive function.Methods.A longitudinal population-based cohort of 6,678 initially nondisabled older adults from a biracial urban community was interviewed at 3-year intervals from 1993 to 2012. Cognitive function was assessed using a standardized global cognitive score, and physical disabilities using activities of daily living (ADL) and instrumental activities of daily living (IADL).Results.During the follow-up period, 2,450 of 6,678 participants (37%) developed ADL and 2,069 of 4,287 participants (48%) developed IADL disability. After adjusting for demographic and physiologic confounders, cognitive function declined a mean of 0.048 unit per year before ADL disability and 0.047 unit per year before IADL disability. In comparison, the rate of cognitive decline accelerated further by 0.076 unit per year (156% increase) after ADL disability and 0.054 unit per year (115% increase) after IADL disability. Severity of ADL and IADL disabilities were also associated with faster cognitive decline following disability.Conclusions.In old age, cognitive function declines substantially faster following physical disability even after controlling for demographic and physiologic characteristics of participants.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 624-630 |
| Number of pages | 7 |
| Journal | Journals of Gerontology - Series A Biological Sciences and Medical Sciences |
| Volume | 68 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2013 |
| Externally published | Yes |
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Keywords
- Activities of daily living
- Cognitive decline
- Instrumental activities of daily living
- Physical disability
ASJC Scopus subject areas
- Aging
- Geriatrics and Gerontology
Cite this
Disability in basic and instrumental activities of daily living is associated with faster rate of decline in cognitive function of older adults. / Rajan, Kumar; Hebert, Liesi E.; Scherr, Paul A.; Mendes De Leon, Carlos F.; Evans, Denis A.
In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 68, No. 5, 01.05.2013, p. 624-630.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Disability in basic and instrumental activities of daily living is associated with faster rate of decline in cognitive function of older adults
AU - Rajan, Kumar
AU - Hebert, Liesi E.
AU - Scherr, Paul A.
AU - Mendes De Leon, Carlos F.
AU - Evans, Denis A.
PY - 2013/5/1
Y1 - 2013/5/1
N2 - Background.The purpose of this study is to examine whether physical disability is associated with faster rate of decline in cognitive function.Methods.A longitudinal population-based cohort of 6,678 initially nondisabled older adults from a biracial urban community was interviewed at 3-year intervals from 1993 to 2012. Cognitive function was assessed using a standardized global cognitive score, and physical disabilities using activities of daily living (ADL) and instrumental activities of daily living (IADL).Results.During the follow-up period, 2,450 of 6,678 participants (37%) developed ADL and 2,069 of 4,287 participants (48%) developed IADL disability. After adjusting for demographic and physiologic confounders, cognitive function declined a mean of 0.048 unit per year before ADL disability and 0.047 unit per year before IADL disability. In comparison, the rate of cognitive decline accelerated further by 0.076 unit per year (156% increase) after ADL disability and 0.054 unit per year (115% increase) after IADL disability. Severity of ADL and IADL disabilities were also associated with faster cognitive decline following disability.Conclusions.In old age, cognitive function declines substantially faster following physical disability even after controlling for demographic and physiologic characteristics of participants.
AB - Background.The purpose of this study is to examine whether physical disability is associated with faster rate of decline in cognitive function.Methods.A longitudinal population-based cohort of 6,678 initially nondisabled older adults from a biracial urban community was interviewed at 3-year intervals from 1993 to 2012. Cognitive function was assessed using a standardized global cognitive score, and physical disabilities using activities of daily living (ADL) and instrumental activities of daily living (IADL).Results.During the follow-up period, 2,450 of 6,678 participants (37%) developed ADL and 2,069 of 4,287 participants (48%) developed IADL disability. After adjusting for demographic and physiologic confounders, cognitive function declined a mean of 0.048 unit per year before ADL disability and 0.047 unit per year before IADL disability. In comparison, the rate of cognitive decline accelerated further by 0.076 unit per year (156% increase) after ADL disability and 0.054 unit per year (115% increase) after IADL disability. Severity of ADL and IADL disabilities were also associated with faster cognitive decline following disability.Conclusions.In old age, cognitive function declines substantially faster following physical disability even after controlling for demographic and physiologic characteristics of participants.
KW - Activities of daily living
KW - Cognitive decline
KW - Instrumental activities of daily living
KW - Physical disability
UR - http://www.scopus.com/inward/record.url?scp=84876244991&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876244991&partnerID=8YFLogxK
U2 - 10.1093/gerona/gls208
DO - 10.1093/gerona/gls208
M3 - Article
C2 - 23105042
AN - SCOPUS:84876244991
VL - 68
SP - 624
EP - 630
JO - The journals of gerontology. Series A, Biological sciences and medical sciences
JF - The journals of gerontology. Series A, Biological sciences and medical sciences
SN - 1079-5006
IS - 5
ER -