The direction of chromosome replication in a temperature sensitive initiation mutant of E. coli (CT28) is shown autoradiographically to be bidirectional. This mode of replication persists even when the rate of replication is reduced by slow growth in succinate minimal medium or in the presence of chloramphenicol. Therefore, although the rate of replication can be affected by certain physiological stimuli, the topology of replication need not be.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of Bacteriology|
|State||Published - 1976|
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology