Direction of deoxyribonucleic acid replication in Escherichia coli under various conditions of cell growth

R. L. Rodriguez, C. I. Davern

Research output: Contribution to journalArticle

5 Scopus citations


The direction of chromosome replication in a temperature sensitive initiation mutant of E. coli (CT28) is shown autoradiographically to be bidirectional. This mode of replication persists even when the rate of replication is reduced by slow growth in succinate minimal medium or in the presence of chloramphenicol. Therefore, although the rate of replication can be affected by certain physiological stimuli, the topology of replication need not be.

Original languageEnglish (US)
Pages (from-to)346-352
Number of pages7
JournalJournal of Bacteriology
Issue number1
StatePublished - 1976


ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology

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