Abstract
A new strategy which employs a process of directed evolution in the search for molecules exhibiting certain desirable properties is reported. By repeating a cycle of peptide synthesis, evaluation of the trypsin inhibitory activities of these peptides and subsequent selection and transformation based on a genetic algorithm, it is possible artificially to induce the evolution of a family of peptides and improve their biological activities. Commencing with a set of 24 randomly generated hexapeptides, a progressive improvement from 16 to 50% average inhibitory activity over six generations, with maximum activities of 80-90% is observed. The emergence of consensus sequences which concur with those previously generated using peptide libraries is also observed.
Original language | English (US) |
---|---|
Pages (from-to) | 2435-2437 |
Number of pages | 3 |
Journal | Journal of the Chemical Society - Perkin Transactions 1 |
Issue number | 20 |
State | Published - 1996 |
Externally published | Yes |
ASJC Scopus subject areas
- Organic Chemistry