Abstract
Five gilts each received intraluteal implants releasing about 4.4 ± 1.1 (Group 1), 15.0 ± 1.1 (Group 2) or 22.4 ± 1.0 (Group 3) μg oestradiol/day as determined by in-vitro incubation of implants of similar weight and oestradiol content. On Day 11 of the oestrous cycle (Day 0 = first day of oestrus), 3 CL in one ovary received oestradiol implants, 3 CL in the other ovary received vehicle implants, and all other CL in both ovaries served as uninjected control CL. An additional group of 6 animals served as controls and included 4 animals receiving bilateral vehicle implants (3 CL per ovary) on Day 11 and 2 unoperated gilts. All animals were slaughtered on Day 19 of their oestrus cycle, and the weight, progesterone content and concentration of each CL were determined. In Group 3 gilts, luteal weight, progesterone content and concentration were greater by 68.7 ± 24.0 mg, 6.54 ± 1.33 μg and 7.54 ± 2.00 ng/ml respectively (P < 0.01) in oestradiol-implanted CL than in vehicle-implanted CL, which appeared to be similar to uninjected control CL. No differences were seen between oestradiol-17β and vehicle-treated CL in CL from gilts in Groups 1 or 2. All CL of Group 3 gilts were heavier and contained a greater content and concentration of progesterone (P < 0.01) than gilts in Groups 1 and 2, and in controls for which the values were similar. These results demonstrate that exogenous oestradiol can directly stimulate the growth of an individual CL; however, the oestradiol release rate must be high enough to maintain all CL bilaterally before this effect is seen.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 125-131 |
| Number of pages | 7 |
| Journal | Journal of Reproduction and Fertility |
| Volume | 87 |
| Issue number | 1 |
| State | Published - 1989 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Physiology
- Embryology
- Obstetrics and Gynecology
Cite this
Direct luteotrophic effect of oestradiol-17β on pig corpora lutea. / Conley, Alan J; Ford, S. P.
In: Journal of Reproduction and Fertility, Vol. 87, No. 1, 1989, p. 125-131.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Direct luteotrophic effect of oestradiol-17β on pig corpora lutea
AU - Conley, Alan J
AU - Ford, S. P.
PY - 1989
Y1 - 1989
N2 - Five gilts each received intraluteal implants releasing about 4.4 ± 1.1 (Group 1), 15.0 ± 1.1 (Group 2) or 22.4 ± 1.0 (Group 3) μg oestradiol/day as determined by in-vitro incubation of implants of similar weight and oestradiol content. On Day 11 of the oestrous cycle (Day 0 = first day of oestrus), 3 CL in one ovary received oestradiol implants, 3 CL in the other ovary received vehicle implants, and all other CL in both ovaries served as uninjected control CL. An additional group of 6 animals served as controls and included 4 animals receiving bilateral vehicle implants (3 CL per ovary) on Day 11 and 2 unoperated gilts. All animals were slaughtered on Day 19 of their oestrus cycle, and the weight, progesterone content and concentration of each CL were determined. In Group 3 gilts, luteal weight, progesterone content and concentration were greater by 68.7 ± 24.0 mg, 6.54 ± 1.33 μg and 7.54 ± 2.00 ng/ml respectively (P < 0.01) in oestradiol-implanted CL than in vehicle-implanted CL, which appeared to be similar to uninjected control CL. No differences were seen between oestradiol-17β and vehicle-treated CL in CL from gilts in Groups 1 or 2. All CL of Group 3 gilts were heavier and contained a greater content and concentration of progesterone (P < 0.01) than gilts in Groups 1 and 2, and in controls for which the values were similar. These results demonstrate that exogenous oestradiol can directly stimulate the growth of an individual CL; however, the oestradiol release rate must be high enough to maintain all CL bilaterally before this effect is seen.
AB - Five gilts each received intraluteal implants releasing about 4.4 ± 1.1 (Group 1), 15.0 ± 1.1 (Group 2) or 22.4 ± 1.0 (Group 3) μg oestradiol/day as determined by in-vitro incubation of implants of similar weight and oestradiol content. On Day 11 of the oestrous cycle (Day 0 = first day of oestrus), 3 CL in one ovary received oestradiol implants, 3 CL in the other ovary received vehicle implants, and all other CL in both ovaries served as uninjected control CL. An additional group of 6 animals served as controls and included 4 animals receiving bilateral vehicle implants (3 CL per ovary) on Day 11 and 2 unoperated gilts. All animals were slaughtered on Day 19 of their oestrus cycle, and the weight, progesterone content and concentration of each CL were determined. In Group 3 gilts, luteal weight, progesterone content and concentration were greater by 68.7 ± 24.0 mg, 6.54 ± 1.33 μg and 7.54 ± 2.00 ng/ml respectively (P < 0.01) in oestradiol-implanted CL than in vehicle-implanted CL, which appeared to be similar to uninjected control CL. No differences were seen between oestradiol-17β and vehicle-treated CL in CL from gilts in Groups 1 or 2. All CL of Group 3 gilts were heavier and contained a greater content and concentration of progesterone (P < 0.01) than gilts in Groups 1 and 2, and in controls for which the values were similar. These results demonstrate that exogenous oestradiol can directly stimulate the growth of an individual CL; however, the oestradiol release rate must be high enough to maintain all CL bilaterally before this effect is seen.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024455430&partnerID=8YFLogxK
M3 - Article
C2 - 2621687
AN - SCOPUS:0024455430
VL - 87
SP - 125
EP - 131
JO - Journal of Reproduction and Fertility
JF - Journal of Reproduction and Fertility
SN - 0022-4251
IS - 1
ER -