Direct ex vivo measurement of CD8+ T-lymphocyte responses to human parvovirus B19

T. Tolfvenstam, A. Oxenius, D. A. Price, Barbara Shacklett, H. M L Spiegel, K. Hedman, O. Norbeck, M. Levi, K. Olsen, M. Kantzanou, D. F. Nixon, K. Broliden, P. Klenerman

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33 Scopus citations

Abstract

Parvovirus B19 is a common human pathogen which can cause severe syndromes, including aplastic anemia and fetal hydrops. The mapping of the first parvovirus B19-derived CD8+ T-lymphocyte epitope is described. This HLA-B35-restricted peptide derives from the nonstructural (NS1) protein and is strongly immunogenic in B19 virus-seropositve donors.

Original languageEnglish (US)
Pages (from-to)540-543
Number of pages4
JournalJournal of Virology
Volume75
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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    Tolfvenstam, T., Oxenius, A., Price, D. A., Shacklett, B., Spiegel, H. M. L., Hedman, K., Norbeck, O., Levi, M., Olsen, K., Kantzanou, M., Nixon, D. F., Broliden, K., & Klenerman, P. (2001). Direct ex vivo measurement of CD8+ T-lymphocyte responses to human parvovirus B19. Journal of Virology, 75(1), 540-543. https://doi.org/10.1128/JVI.75.1.540-543.2001