Direct ex vivo measurement of CD8+ T-lymphocyte responses to human parvovirus B19

T. Tolfvenstam, A. Oxenius, D. A. Price, Barbara Shacklett, H. M L Spiegel, K. Hedman, O. Norbeck, M. Levi, K. Olsen, M. Kantzanou, D. F. Nixon, K. Broliden, P. Klenerman

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Parvovirus B19 is a common human pathogen which can cause severe syndromes, including aplastic anemia and fetal hydrops. The mapping of the first parvovirus B19-derived CD8+ T-lymphocyte epitope is described. This HLA-B35-restricted peptide derives from the nonstructural (NS1) protein and is strongly immunogenic in B19 virus-seropositve donors.

Original languageEnglish (US)
Pages (from-to)540-543
Number of pages4
JournalJournal of Virology
Volume75
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

B19 virus
Human Parvovirus B19
Parvovirus
Protoparvovirus
HLA-B35 Antigen
T-lymphocytes
T-Lymphocytes
Hydrops Fetalis
T-Lymphocyte Epitopes
Aplastic Anemia
anemia
epitopes
peptides
Peptides
pathogens
Proteins
proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Tolfvenstam, T., Oxenius, A., Price, D. A., Shacklett, B., Spiegel, H. M. L., Hedman, K., ... Klenerman, P. (2001). Direct ex vivo measurement of CD8+ T-lymphocyte responses to human parvovirus B19. Journal of Virology, 75(1), 540-543. https://doi.org/10.1128/JVI.75.1.540-543.2001

Direct ex vivo measurement of CD8+ T-lymphocyte responses to human parvovirus B19. / Tolfvenstam, T.; Oxenius, A.; Price, D. A.; Shacklett, Barbara; Spiegel, H. M L; Hedman, K.; Norbeck, O.; Levi, M.; Olsen, K.; Kantzanou, M.; Nixon, D. F.; Broliden, K.; Klenerman, P.

In: Journal of Virology, Vol. 75, No. 1, 2001, p. 540-543.

Research output: Contribution to journalArticle

Tolfvenstam, T, Oxenius, A, Price, DA, Shacklett, B, Spiegel, HML, Hedman, K, Norbeck, O, Levi, M, Olsen, K, Kantzanou, M, Nixon, DF, Broliden, K & Klenerman, P 2001, 'Direct ex vivo measurement of CD8+ T-lymphocyte responses to human parvovirus B19', Journal of Virology, vol. 75, no. 1, pp. 540-543. https://doi.org/10.1128/JVI.75.1.540-543.2001
Tolfvenstam, T. ; Oxenius, A. ; Price, D. A. ; Shacklett, Barbara ; Spiegel, H. M L ; Hedman, K. ; Norbeck, O. ; Levi, M. ; Olsen, K. ; Kantzanou, M. ; Nixon, D. F. ; Broliden, K. ; Klenerman, P. / Direct ex vivo measurement of CD8+ T-lymphocyte responses to human parvovirus B19. In: Journal of Virology. 2001 ; Vol. 75, No. 1. pp. 540-543.
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