Direct ex vivo measurement of CD8+ T-lymphocyte responses to human parvovirus B19

T. Tolfvenstam; A. Oxenius; D. A. Price; Barbara Shacklett; H. M L Spiegel; K. Hedman; O. Norbeck; M. Levi; K. Olsen; M. Kantzanou; D. F. Nixon; K. Broliden; P. Klenerman

doi:10.1128/JVI.75.1.540-543.2001

Direct ex vivo measurement of CD8⁺ T-lymphocyte responses to human parvovirus B19

T. Tolfvenstam, A. Oxenius, D. A. Price, Barbara Shacklett, H. M L Spiegel, K. Hedman, O. Norbeck, M. Levi, K. Olsen, M. Kantzanou, D. F. Nixon, K. Broliden, P. Klenerman

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Parvovirus B19 is a common human pathogen which can cause severe syndromes, including aplastic anemia and fetal hydrops. The mapping of the first parvovirus B19-derived CD8⁺ T-lymphocyte epitope is described. This HLA-B35-restricted peptide derives from the nonstructural (NS1) protein and is strongly immunogenic in B19 virus-seropositve donors.

Original language	English (US)
Pages (from-to)	540-543
Number of pages	4
Journal	Journal of Virology
Volume	75
Issue number	1
DOIs	https://doi.org/10.1128/JVI.75.1.540-543.2001
State	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Immunology

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10.1128/JVI.75.1.540-543.2001

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Direct ex vivo measurement of CD8⁺ T-lymphocyte responses to human parvovirus B19. / Tolfvenstam, T.; Oxenius, A.; Price, D. A.; Shacklett, Barbara; Spiegel, H. M L; Hedman, K.; Norbeck, O.; Levi, M.; Olsen, K.; Kantzanou, M.; Nixon, D. F.; Broliden, K.; Klenerman, P.

In: Journal of Virology, Vol. 75, No. 1, 2001, p. 540-543.

Research output: Contribution to journal › Article › peer-review

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AU - Tolfvenstam, T.

AU - Oxenius, A.

AU - Price, D. A.

AU - Shacklett, Barbara

AU - Spiegel, H. M L

AU - Hedman, K.

AU - Norbeck, O.

AU - Levi, M.

AU - Olsen, K.

AU - Kantzanou, M.

AU - Nixon, D. F.

AU - Broliden, K.

AU - Klenerman, P.

PY - 2001

Y1 - 2001

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AB - Parvovirus B19 is a common human pathogen which can cause severe syndromes, including aplastic anemia and fetal hydrops. The mapping of the first parvovirus B19-derived CD8+ T-lymphocyte epitope is described. This HLA-B35-restricted peptide derives from the nonstructural (NS1) protein and is strongly immunogenic in B19 virus-seropositve donors.

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Direct ex vivo measurement of CD8⁺ T-lymphocyte responses to human parvovirus B19

Abstract

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