Dipolar cycloadditions in solid-phase organic synthesis (SPOS)

Eric J. Kantorowski, Mark J. Kurth

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


We present a concise review of polymer-supported 1,3-dipolar cycloaddition reactions. Nitrile oxide and azomethine ylides constitute the two types of 1,3-dipoles which have been used in conjunction with solid-phase organic synthesis. These cycloaddition reactions on solid phase are generally of equal or greater efficiency than the analogous solution-phase reactions.

Original languageEnglish (US)
Pages (from-to)207-216
Number of pages10
JournalMolecular Diversity
Issue number4
StatePublished - 1997


  • 1,3-Dipolar cycloadditions
  • [3+2] Cycloadditions
  • Azomethine ylide
  • Nitrile oxide ylide
  • Solid-phase organic synthesis (SPOS)

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry


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