Dimsyl anion in the monoalkylation of solid-phase alkyl sulfones

Wei Chieh Cheng; Chu Chung Lin; Mark J. Kurth

doi:10.1016/S0040-4039(02)00423-9

Dimsyl anion in the monoalkylation of solid-phase alkyl sulfones

Wei Chieh Cheng, Chu Chung Lin, Mark J. Kurth

Chemistry

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Polymer-bound α-sulfonyl monocarbanions can be generated very effectively with dimsyl anion. The highly efficient and convenient protocols presented here report the preparation of α,β-unsaturated ketones and vinylaryl compounds using dimsyl anion to achieve the key solid-phase α-sulfonyl monocarbanion alkylation step.

Original language	English (US)
Pages (from-to)	2967-2970
Number of pages	4
Journal	Tetrahedron Letters
Volume	43
Issue number	16
DOIs	https://doi.org/10.1016/S0040-4039(02)00423-9
State	Published - Apr 15 2002

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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title = "Dimsyl anion in the monoalkylation of solid-phase alkyl sulfones",

abstract = "Polymer-bound α-sulfonyl monocarbanions can be generated very effectively with dimsyl anion. The highly efficient and convenient protocols presented here report the preparation of α,β-unsaturated ketones and vinylaryl compounds using dimsyl anion to achieve the key solid-phase α-sulfonyl monocarbanion alkylation step.",

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AU - Lin, Chu Chung

AU - Kurth, Mark J.

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Y1 - 2002/4/15

N2 - Polymer-bound α-sulfonyl monocarbanions can be generated very effectively with dimsyl anion. The highly efficient and convenient protocols presented here report the preparation of α,β-unsaturated ketones and vinylaryl compounds using dimsyl anion to achieve the key solid-phase α-sulfonyl monocarbanion alkylation step.

AB - Polymer-bound α-sulfonyl monocarbanions can be generated very effectively with dimsyl anion. The highly efficient and convenient protocols presented here report the preparation of α,β-unsaturated ketones and vinylaryl compounds using dimsyl anion to achieve the key solid-phase α-sulfonyl monocarbanion alkylation step.

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