Abstract
The neuregulin receptor tyrosine kinase Erb-b4, initially linked to early cardiac development, is shown here to play a critical role in adult cardiac function. In wild-type mice, Erb-b4 protein localized to Z lines and to intercalated disks, suggesting a role in subcellular and intercellular communications of cardiomyocytes. Conditional inactivation of erb-b4 in ventricular muscle cells led to a severe dilated cardiomyopathy, characterized by thinned ventricular walls with eccentric hypertrophy, reduced contractility, and delayed conduction. This cardiac dysfunction may account for premature death in adult erb-b4-knockout mice. This study establishes a critical role for Erb-b4 in the maintenance of normal postnatal cardiac structure and function.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Physiology - Heart and Circulatory Physiology |
| Volume | 289 |
| Issue number | 3 58-3 |
| DOIs | |
| State | Published - Sep 2005 |
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Keywords
- Conditional knockout
- erb-b2
- Heart
- Mouse
- Neuregulin
ASJC Scopus subject areas
- Physiology
Cite this
Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle. / García-Rivello, Hernán; Taranda, Julián; Said, Matilde; Cabeza-Meckert, Patricia; Vila-Petroff, Martin; Scaglione, Jorge; Ghio, Sergio; Chen, Ju; Lai, Cary; Laguens, Ruben P.; Lloyd, Kevin C K; Hertig, Cecilia M.
In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 289, No. 3 58-3, 09.2005.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle
AU - García-Rivello, Hernán
AU - Taranda, Julián
AU - Said, Matilde
AU - Cabeza-Meckert, Patricia
AU - Vila-Petroff, Martin
AU - Scaglione, Jorge
AU - Ghio, Sergio
AU - Chen, Ju
AU - Lai, Cary
AU - Laguens, Ruben P.
AU - Lloyd, Kevin C K
AU - Hertig, Cecilia M.
PY - 2005/9
Y1 - 2005/9
N2 - The neuregulin receptor tyrosine kinase Erb-b4, initially linked to early cardiac development, is shown here to play a critical role in adult cardiac function. In wild-type mice, Erb-b4 protein localized to Z lines and to intercalated disks, suggesting a role in subcellular and intercellular communications of cardiomyocytes. Conditional inactivation of erb-b4 in ventricular muscle cells led to a severe dilated cardiomyopathy, characterized by thinned ventricular walls with eccentric hypertrophy, reduced contractility, and delayed conduction. This cardiac dysfunction may account for premature death in adult erb-b4-knockout mice. This study establishes a critical role for Erb-b4 in the maintenance of normal postnatal cardiac structure and function.
AB - The neuregulin receptor tyrosine kinase Erb-b4, initially linked to early cardiac development, is shown here to play a critical role in adult cardiac function. In wild-type mice, Erb-b4 protein localized to Z lines and to intercalated disks, suggesting a role in subcellular and intercellular communications of cardiomyocytes. Conditional inactivation of erb-b4 in ventricular muscle cells led to a severe dilated cardiomyopathy, characterized by thinned ventricular walls with eccentric hypertrophy, reduced contractility, and delayed conduction. This cardiac dysfunction may account for premature death in adult erb-b4-knockout mice. This study establishes a critical role for Erb-b4 in the maintenance of normal postnatal cardiac structure and function.
KW - Conditional knockout
KW - erb-b2
KW - Heart
KW - Mouse
KW - Neuregulin
UR - http://www.scopus.com/inward/record.url?scp=23944477855&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23944477855&partnerID=8YFLogxK
U2 - 10.1152/ajpheart.00048.2005
DO - 10.1152/ajpheart.00048.2005
M3 - Article
C2 - 15863464
AN - SCOPUS:23944477855
VL - 289
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
SN - 1931-857X
IS - 3 58-3
ER -