Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle

Hernán García-Rivello, Julián Taranda, Matilde Said, Patricia Cabeza-Meckert, Martin Vila-Petroff, Jorge Scaglione, Sergio Ghio, Ju Chen, Cary Lai, Ruben P. Laguens, Kevin C K Lloyd, Cecilia M. Hertig

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

The neuregulin receptor tyrosine kinase Erb-b4, initially linked to early cardiac development, is shown here to play a critical role in adult cardiac function. In wild-type mice, Erb-b4 protein localized to Z lines and to intercalated disks, suggesting a role in subcellular and intercellular communications of cardiomyocytes. Conditional inactivation of erb-b4 in ventricular muscle cells led to a severe dilated cardiomyopathy, characterized by thinned ventricular walls with eccentric hypertrophy, reduced contractility, and delayed conduction. This cardiac dysfunction may account for premature death in adult erb-b4-knockout mice. This study establishes a critical role for Erb-b4 in the maintenance of normal postnatal cardiac structure and function.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume289
Issue number3 58-3
DOIs
StatePublished - Sep 2005

Fingerprint

Neuregulins
Premature Mortality
Dilated Cardiomyopathy
Receptor Protein-Tyrosine Kinases
Cardiac Myocytes
Knockout Mice
Muscle Cells
Hypertrophy
Maintenance
Muscles
Proteins

Keywords

  • Conditional knockout
  • erb-b2
  • Heart
  • Mouse
  • Neuregulin

ASJC Scopus subject areas

  • Physiology

Cite this

García-Rivello, H., Taranda, J., Said, M., Cabeza-Meckert, P., Vila-Petroff, M., Scaglione, J., ... Hertig, C. M. (2005). Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle. American Journal of Physiology - Heart and Circulatory Physiology, 289(3 58-3). https://doi.org/10.1152/ajpheart.00048.2005

Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle. / García-Rivello, Hernán; Taranda, Julián; Said, Matilde; Cabeza-Meckert, Patricia; Vila-Petroff, Martin; Scaglione, Jorge; Ghio, Sergio; Chen, Ju; Lai, Cary; Laguens, Ruben P.; Lloyd, Kevin C K; Hertig, Cecilia M.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 289, No. 3 58-3, 09.2005.

Research output: Contribution to journalArticle

García-Rivello, H, Taranda, J, Said, M, Cabeza-Meckert, P, Vila-Petroff, M, Scaglione, J, Ghio, S, Chen, J, Lai, C, Laguens, RP, Lloyd, KCK & Hertig, CM 2005, 'Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle', American Journal of Physiology - Heart and Circulatory Physiology, vol. 289, no. 3 58-3. https://doi.org/10.1152/ajpheart.00048.2005
García-Rivello H, Taranda J, Said M, Cabeza-Meckert P, Vila-Petroff M, Scaglione J et al. Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle. American Journal of Physiology - Heart and Circulatory Physiology. 2005 Sep;289(3 58-3). https://doi.org/10.1152/ajpheart.00048.2005
García-Rivello, Hernán ; Taranda, Julián ; Said, Matilde ; Cabeza-Meckert, Patricia ; Vila-Petroff, Martin ; Scaglione, Jorge ; Ghio, Sergio ; Chen, Ju ; Lai, Cary ; Laguens, Ruben P. ; Lloyd, Kevin C K ; Hertig, Cecilia M. / Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle. In: American Journal of Physiology - Heart and Circulatory Physiology. 2005 ; Vol. 289, No. 3 58-3.
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