Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle

Hernán García-Rivello, Julián Taranda, Matilde Said, Patricia Cabeza-Meckert, Martin Vila-Petroff, Jorge Scaglione, Sergio Ghio, Ju Chen, Cary Lai, Ruben P. Laguens, Kevin C K Lloyd, Cecilia M. Hertig

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

The neuregulin receptor tyrosine kinase Erb-b4, initially linked to early cardiac development, is shown here to play a critical role in adult cardiac function. In wild-type mice, Erb-b4 protein localized to Z lines and to intercalated disks, suggesting a role in subcellular and intercellular communications of cardiomyocytes. Conditional inactivation of erb-b4 in ventricular muscle cells led to a severe dilated cardiomyopathy, characterized by thinned ventricular walls with eccentric hypertrophy, reduced contractility, and delayed conduction. This cardiac dysfunction may account for premature death in adult erb-b4-knockout mice. This study establishes a critical role for Erb-b4 in the maintenance of normal postnatal cardiac structure and function.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume289
Issue number3 58-3
DOIs
StatePublished - Sep 2005

Keywords

  • Conditional knockout
  • erb-b2
  • Heart
  • Mouse
  • Neuregulin

ASJC Scopus subject areas

  • Physiology

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    García-Rivello, H., Taranda, J., Said, M., Cabeza-Meckert, P., Vila-Petroff, M., Scaglione, J., Ghio, S., Chen, J., Lai, C., Laguens, R. P., Lloyd, K. C. K., & Hertig, C. M. (2005). Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle. American Journal of Physiology - Heart and Circulatory Physiology, 289(3 58-3). https://doi.org/10.1152/ajpheart.00048.2005