Dilated cardiomyopathy in an American cocker spaniel with taurine deficiency.

B. J. Gavaghan, Mark D Kittleson

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

An American Cocker Spaniel with low plasma taurine concentration (< 2 nmol/mL) was presented with dyspnoea associated with pulmonary oedema and a left ventricular shortening fraction of 9%. Emergency therapy with furosemide, dobutamine, nitroglycerine and oxygen supplementation led to a good response. Chronic therapy was started with enalapril, furosemide, digoxin and taurine. Improvement in all echocardiographic indices were noted over a 22 week follow-up, most notably an increase in left ventricular shortening fraction to 20%, a decrease of E-point septal separation from 14 mm to 7 mm and marked left ventricular remodelling. This degree of improvement in myocardial function may represent a direct link between dilated cardiomyopathy in the American Cocker Spaniel and plasma taurine deficiency. Alternatively, this response may reflect a breed-related cardiomyopathy with a natural history and therapeutic response not commonly seen in the more common large breed cardiomyopathy presentations.

Original languageEnglish (US)
Pages (from-to)862-868
Number of pages7
JournalAustralian Veterinary Journal
Volume75
Issue number12
StatePublished - Dec 1997

ASJC Scopus subject areas

  • veterinary(all)

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