Diffusion tensor imaging of tract involvement in children with pontine tumors

Kathleen J. Helton, N. S. Phillips, R. B. Khan, F. A. Boop, R. A. Sanford, P. Zou, Chin-Shang Li, J. W. Langston, R. J. Ogg

Research output: Contribution to journalArticle

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Abstract

BACKGROUND AND PURPOSE: Conventional MR imaging permits subcategorization of brain stem tumors by location and focality; however, assessment of white matter tract involvement by tumor is limited. Diffusion tensor imaging (DTI) is a promising method for visualizing white matter tract tumor involvement supratentorially. We investigated the ability of DTI to visualize and quantify white matter tract involvement in pontine tumors. METHODS AND MATERIALS: DTI data (echo-planar, 1.5T) were retrospectively analyzed in 7 patients with pontine tumors (6 diffuse, 1 focal), 4 patient controls, and 5 normal volunteers. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were calculated from the diffusion tensor in 6 regions of interest: bilateral corticospinal tracts, transverse pontine fibers, and medial lemnisci. Relationships between FA and ADC values and results of the neurologic examinations were evaluated. RESULTS: The corticospinal tracts and transverse pontine fibers were affected more often than the medial lemnisci. The DTI parameters (FA and ADC) were significantly altered in all tracts of patients with pontine tumors (P < .05), compared with those values in the control groups. A marginally significant (P = .057) association was seen between the severity of cranial nerve deficit and decreased FA. CONCLUSION: DTI provided superior visualization and quantification of tumor involvement in motor, sensory, and transverse pontine tracts, compared with information provided by conventional MR imaging. Thus, DTI may be a sensitive measure of tract invasion. Further prospective studies are warranted to assess the ability of DTI to delineate tumor focality and improve risk stratification in children with pontine tumors.

Original languageEnglish (US)
Pages (from-to)786-793
Number of pages8
JournalAmerican Journal of Neuroradiology
Volume27
Issue number4
StatePublished - Apr 2006
Externally publishedYes

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Brain Stem Neoplasms
Diffusion Tensor Imaging
Anisotropy
Pyramidal Tracts
Neoplasms
Cranial Nerves
Neurologic Examination
Healthy Volunteers
Prospective Studies
Control Groups

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Helton, K. J., Phillips, N. S., Khan, R. B., Boop, F. A., Sanford, R. A., Zou, P., ... Ogg, R. J. (2006). Diffusion tensor imaging of tract involvement in children with pontine tumors. American Journal of Neuroradiology, 27(4), 786-793.

Diffusion tensor imaging of tract involvement in children with pontine tumors. / Helton, Kathleen J.; Phillips, N. S.; Khan, R. B.; Boop, F. A.; Sanford, R. A.; Zou, P.; Li, Chin-Shang; Langston, J. W.; Ogg, R. J.

In: American Journal of Neuroradiology, Vol. 27, No. 4, 04.2006, p. 786-793.

Research output: Contribution to journalArticle

Helton, KJ, Phillips, NS, Khan, RB, Boop, FA, Sanford, RA, Zou, P, Li, C-S, Langston, JW & Ogg, RJ 2006, 'Diffusion tensor imaging of tract involvement in children with pontine tumors', American Journal of Neuroradiology, vol. 27, no. 4, pp. 786-793.
Helton KJ, Phillips NS, Khan RB, Boop FA, Sanford RA, Zou P et al. Diffusion tensor imaging of tract involvement in children with pontine tumors. American Journal of Neuroradiology. 2006 Apr;27(4):786-793.
Helton, Kathleen J. ; Phillips, N. S. ; Khan, R. B. ; Boop, F. A. ; Sanford, R. A. ; Zou, P. ; Li, Chin-Shang ; Langston, J. W. ; Ogg, R. J. / Diffusion tensor imaging of tract involvement in children with pontine tumors. In: American Journal of Neuroradiology. 2006 ; Vol. 27, No. 4. pp. 786-793.
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AU - Phillips, N. S.

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AU - Zou, P.

AU - Li, Chin-Shang

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