Diffusion tensor imaging in male premutation carriers of the fragile X mental retardation gene

Ryu Ichiro Hashimoto, Siddharth Srivastava, Flora Tassone, Randi J Hagerman, Susan M. Rivera

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Older male premutation carriers of the FMR1 gene are associated with the risk of developing a late-onset neurodegenerative disorder, fragile X-associated tremor/ataxia syndrome. Although previous postmortem and in vivo magnetic resonance imaging studies have indicated white matter pathology, the regional selectivity of abnormalities, as well as their relationship with molecular variables of the FMR1 gene, has not been investigated. In this study, we used diffusion tensor imaging to study male premutation carriers with and without fragile X-associated tremor/ataxia syndrome and healthy sex-matched controls. We performed a tract of interest analysis for fractional anisotropy and axial and radial diffusivities of major white matter tracts in the cerebellar-brain stem and limbic systems. Compared with healthy controls, patients with fragile X-associated tremor/ataxia syndrome showed significant reductions of fractional anisotropy in multiple white matter tracts, including the middle cerebellar peduncle, superior cerebellar peduncle, cerebral peduncle, and the fornix and stria terminalis. Significant reduction of fractional anisotropy in these tracts was confirmed by voxel-wise analysis using tract-based spatial statistics. Analysis of axial and radial diffusivities showed significant elevation of these measures in middle cerebellar peduncle, even among premutation carriers without fragile X-associated tremor/ataxia syndrome. Furthermore, regression analyses demonstrated a clear inverted U-shaped relationship between CGG-repeat size and axial and radial diffusivities in middle cerebellar peduncle. These results provide new evidence from diffusion tensor imaging for white matter abnormalities in the cerebellar-brain stem and limbic systems among individuals with the fragile X premutation and suggest the involvement of molecular mechanisms related to the FMR1 gene in their white matter pathology.

Original languageEnglish (US)
Pages (from-to)1329-1336
Number of pages8
JournalMovement Disorders
Volume26
Issue number7
DOIs
StatePublished - Jun 2011

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Diffusion Tensor Imaging
Intellectual Disability
Anisotropy
Limbic System
Genes
Brain Stem
Pathology
Neurodegenerative Diseases
Regression Analysis
Magnetic Resonance Imaging
White Matter
Fragile X Tremor Ataxia Syndrome
Middle Cerebellar Peduncle

Keywords

  • Cerebellum
  • Diffusion tensor imaging
  • FMR1
  • Fragile X-associated tremor/ataxia syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Diffusion tensor imaging in male premutation carriers of the fragile X mental retardation gene. / Hashimoto, Ryu Ichiro; Srivastava, Siddharth; Tassone, Flora; Hagerman, Randi J; Rivera, Susan M.

In: Movement Disorders, Vol. 26, No. 7, 06.2011, p. 1329-1336.

Research output: Contribution to journalArticle

Hashimoto, Ryu Ichiro ; Srivastava, Siddharth ; Tassone, Flora ; Hagerman, Randi J ; Rivera, Susan M. / Diffusion tensor imaging in male premutation carriers of the fragile X mental retardation gene. In: Movement Disorders. 2011 ; Vol. 26, No. 7. pp. 1329-1336.
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