Diffusion MRI: A new strategy for assessment of cancer therapeutic efficacy

Thomas L. Chenevert, Charles R. Meyer, Bradford A. Moffat, Alnawaz Rehemtulla, Suresh K. Mukherji, Stephen S. Gebarski, Douglas J. Quint, Patricia L. Robertson, Theodore S. Lawrence, Larry Junck, Jeremy M G Taylor, Timothy D. Johnson, Qian Dong, Karin M. Muraszko, James A Brunberg, Brian D. Ross

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

The use of anatomical imaging in clinical oncology practice traditionally relies on comparison of patient scans acquired before and following completion of therapeutic intervention. Therapeutic success is typically determined from inspection of gross anatomical images to assess changes in tumor size. Imaging could provide significant additional insight into therapeutic impact if a specific parameter or combination of parameters could be identified which reflect tissue changes at the cellular or physiologic level. This would provide an early indicator of treatment response/outcome in an individual patient before completion of therapy. Moreover, response of a tumor to therapeutic intervention may be heterogeneous. The use of imaging could assist in delineating therapeutic-induced spatial heterogeneity within a tumor mass by providing information related to specific regions that are resistant or responsive to treatment. Largely untapped potential resides in exploratory methods such as diffusion MRI, which is a non-volumetric intravoxel measure of tumor response based upon water molecular mobility. Alterations in water mobility reflect changes in tissue structure at the cellular level. While the clinical utility of diffusion MRI for oncologic practice is still under active investigation, this overview on the use of diffusion MRI for the evaluation of brain tumors will serve to introduce how this approach may be applied in the future for the management of patients with solid tumors.

Original languageEnglish (US)
Pages (from-to)336-343
Number of pages8
JournalMolecular Imaging
Volume1
Issue number4
DOIs
StatePublished - Oct 2002

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Diffusion Magnetic Resonance Imaging
Magnetic resonance imaging
Tumors
Neoplasms
Imaging techniques
Therapeutics
Tissue
Oncology
Medical Oncology
Water
Cellular Structures
Brain
Brain Neoplasms
Inspection

Keywords

  • Brain tumors
  • Cancer treatment
  • Diffusion MRI
  • Molecular imaging

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Chenevert, T. L., Meyer, C. R., Moffat, B. A., Rehemtulla, A., Mukherji, S. K., Gebarski, S. S., ... Ross, B. D. (2002). Diffusion MRI: A new strategy for assessment of cancer therapeutic efficacy. Molecular Imaging, 1(4), 336-343. https://doi.org/10.1162/153535002321093945

Diffusion MRI : A new strategy for assessment of cancer therapeutic efficacy. / Chenevert, Thomas L.; Meyer, Charles R.; Moffat, Bradford A.; Rehemtulla, Alnawaz; Mukherji, Suresh K.; Gebarski, Stephen S.; Quint, Douglas J.; Robertson, Patricia L.; Lawrence, Theodore S.; Junck, Larry; Taylor, Jeremy M G; Johnson, Timothy D.; Dong, Qian; Muraszko, Karin M.; Brunberg, James A; Ross, Brian D.

In: Molecular Imaging, Vol. 1, No. 4, 10.2002, p. 336-343.

Research output: Contribution to journalArticle

Chenevert, TL, Meyer, CR, Moffat, BA, Rehemtulla, A, Mukherji, SK, Gebarski, SS, Quint, DJ, Robertson, PL, Lawrence, TS, Junck, L, Taylor, JMG, Johnson, TD, Dong, Q, Muraszko, KM, Brunberg, JA & Ross, BD 2002, 'Diffusion MRI: A new strategy for assessment of cancer therapeutic efficacy', Molecular Imaging, vol. 1, no. 4, pp. 336-343. https://doi.org/10.1162/153535002321093945
Chenevert TL, Meyer CR, Moffat BA, Rehemtulla A, Mukherji SK, Gebarski SS et al. Diffusion MRI: A new strategy for assessment of cancer therapeutic efficacy. Molecular Imaging. 2002 Oct;1(4):336-343. https://doi.org/10.1162/153535002321093945
Chenevert, Thomas L. ; Meyer, Charles R. ; Moffat, Bradford A. ; Rehemtulla, Alnawaz ; Mukherji, Suresh K. ; Gebarski, Stephen S. ; Quint, Douglas J. ; Robertson, Patricia L. ; Lawrence, Theodore S. ; Junck, Larry ; Taylor, Jeremy M G ; Johnson, Timothy D. ; Dong, Qian ; Muraszko, Karin M. ; Brunberg, James A ; Ross, Brian D. / Diffusion MRI : A new strategy for assessment of cancer therapeutic efficacy. In: Molecular Imaging. 2002 ; Vol. 1, No. 4. pp. 336-343.
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