Diffuse periventricular calcification and brain atrophy: A case of neonatal central nervous system cytomegalovirus infection

Thomas Ray Sanchez, Mitchell D. Datlow, Anna E. Nidecker

Research output: Contribution to journalArticle

6 Scopus citations


TORCH refers to the most common congenitally acquired infections: toxoplasma, rubella, cytomegalovirus, and herpes simplex virus. Neonatal cytomegalovirus infection remains a common cause of congenital infection worldwide with effects ranging from hearing impairment to significant neurological morbidity. We report a case of a term neonate with ventriculomegaly on prenatal ultrasound who presented with low birth weight, small head circumference, hepatosplenomegaly, and purpuric rash on physical exam. Central nervous system cytomegalovirus infection typically shows periventricular calcifications and associated deep white matter damage and ventriculomegaly. Ultrasound, computed tomography, and magnetic resonance imaging have different roles in the diagnosis of congenital central nervous system cytomegalovirus infection. Many imaging features of congenital cytomegalovirus are distinctive, and can spur a diagnostic work-up as well as help provide a prognosis.

Original languageEnglish (US)
Pages (from-to)314-316
Number of pages3
JournalNeuroradiology Journal
Issue number5
StatePublished - Oct 1 2016



  • congenital CNS infection
  • cytomegalovirus
  • TORCH infection

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this