Differing actions of dietary protein and enalapril on renal function and proteinuria

Florence N. Hutchison, Victor I. Martin, Hardin Jones, George A. Kaysen

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Albuminuria (UalbV) increases in proportion to dietary protein in rats with passive Heymann nephritis. To determine whether a similar relationship existed in normal animals, 14 normal rats were switched from an 8.5% protein diet (LP) to a 40% protein diet (HP). Initially UalbV and glomerular filtration rate (GFR) increased in parallel, but GFR ceased to increase after 48 h while UalbV continued to increase, causing a significant increase in fractional renal clearance of albumin (FCalb). In contrast, HP for 4 days caused only a transient increase in GFR in nephrotic rats but effected a threefold sustained increase in UalbV. Pretreatment of nephrotic rats with enalapril blunted but did not entirely prevent the increase in UalbV after switching to HP and did not affect the increase or subsequent decline in GFR. Treatment with enalapril for 10 days reduced UalbV and FCalb in nephrotic rats fed either LP or HP. The similar pattern of changes in urinary albumin excretion in normal and nephrotic rats after dietary protein augmentation suggests that dietary protein may modify UalbV by the same process in both normal and nephrotic animals. The increases in UalbV and GFR resulting from dietary protein augmentation represent parallel but independent processes, since only the proteinuric response is modified by converting enzyme inhibition. Dietary protein restriction and converting enzyme inhibition exert an additive effect to reduce UalbV.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume258
Issue number1 27-1
StatePublished - 1990

Fingerprint

Enalapril
Dietary Proteins
Proteinuria
Glomerular Filtration Rate
Kidney
Albumins
Diet
Membranous Glomerulonephritis
Albuminuria
Enzymes
Proteins

Keywords

  • Albuminuria
  • Angiotensin
  • Angiotensin converting-enzyme inhibitor
  • Glomerular filtration rate
  • Passive heymann nephritis

ASJC Scopus subject areas

  • Physiology

Cite this

Differing actions of dietary protein and enalapril on renal function and proteinuria. / Hutchison, Florence N.; Martin, Victor I.; Jones, Hardin; Kaysen, George A.

In: American Journal of Physiology - Renal Fluid and Electrolyte Physiology, Vol. 258, No. 1 27-1, 1990.

Research output: Contribution to journalArticle

@article{c9bb1e223f4e47ed9b217b7ed1887a74,
title = "Differing actions of dietary protein and enalapril on renal function and proteinuria",
abstract = "Albuminuria (UalbV) increases in proportion to dietary protein in rats with passive Heymann nephritis. To determine whether a similar relationship existed in normal animals, 14 normal rats were switched from an 8.5{\%} protein diet (LP) to a 40{\%} protein diet (HP). Initially UalbV and glomerular filtration rate (GFR) increased in parallel, but GFR ceased to increase after 48 h while UalbV continued to increase, causing a significant increase in fractional renal clearance of albumin (FCalb). In contrast, HP for 4 days caused only a transient increase in GFR in nephrotic rats but effected a threefold sustained increase in UalbV. Pretreatment of nephrotic rats with enalapril blunted but did not entirely prevent the increase in UalbV after switching to HP and did not affect the increase or subsequent decline in GFR. Treatment with enalapril for 10 days reduced UalbV and FCalb in nephrotic rats fed either LP or HP. The similar pattern of changes in urinary albumin excretion in normal and nephrotic rats after dietary protein augmentation suggests that dietary protein may modify UalbV by the same process in both normal and nephrotic animals. The increases in UalbV and GFR resulting from dietary protein augmentation represent parallel but independent processes, since only the proteinuric response is modified by converting enzyme inhibition. Dietary protein restriction and converting enzyme inhibition exert an additive effect to reduce UalbV.",
keywords = "Albuminuria, Angiotensin, Angiotensin converting-enzyme inhibitor, Glomerular filtration rate, Passive heymann nephritis",
author = "Hutchison, {Florence N.} and Martin, {Victor I.} and Hardin Jones and Kaysen, {George A.}",
year = "1990",
language = "English (US)",
volume = "258",
journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "1 27-1",

}

TY - JOUR

T1 - Differing actions of dietary protein and enalapril on renal function and proteinuria

AU - Hutchison, Florence N.

AU - Martin, Victor I.

AU - Jones, Hardin

AU - Kaysen, George A.

PY - 1990

Y1 - 1990

N2 - Albuminuria (UalbV) increases in proportion to dietary protein in rats with passive Heymann nephritis. To determine whether a similar relationship existed in normal animals, 14 normal rats were switched from an 8.5% protein diet (LP) to a 40% protein diet (HP). Initially UalbV and glomerular filtration rate (GFR) increased in parallel, but GFR ceased to increase after 48 h while UalbV continued to increase, causing a significant increase in fractional renal clearance of albumin (FCalb). In contrast, HP for 4 days caused only a transient increase in GFR in nephrotic rats but effected a threefold sustained increase in UalbV. Pretreatment of nephrotic rats with enalapril blunted but did not entirely prevent the increase in UalbV after switching to HP and did not affect the increase or subsequent decline in GFR. Treatment with enalapril for 10 days reduced UalbV and FCalb in nephrotic rats fed either LP or HP. The similar pattern of changes in urinary albumin excretion in normal and nephrotic rats after dietary protein augmentation suggests that dietary protein may modify UalbV by the same process in both normal and nephrotic animals. The increases in UalbV and GFR resulting from dietary protein augmentation represent parallel but independent processes, since only the proteinuric response is modified by converting enzyme inhibition. Dietary protein restriction and converting enzyme inhibition exert an additive effect to reduce UalbV.

AB - Albuminuria (UalbV) increases in proportion to dietary protein in rats with passive Heymann nephritis. To determine whether a similar relationship existed in normal animals, 14 normal rats were switched from an 8.5% protein diet (LP) to a 40% protein diet (HP). Initially UalbV and glomerular filtration rate (GFR) increased in parallel, but GFR ceased to increase after 48 h while UalbV continued to increase, causing a significant increase in fractional renal clearance of albumin (FCalb). In contrast, HP for 4 days caused only a transient increase in GFR in nephrotic rats but effected a threefold sustained increase in UalbV. Pretreatment of nephrotic rats with enalapril blunted but did not entirely prevent the increase in UalbV after switching to HP and did not affect the increase or subsequent decline in GFR. Treatment with enalapril for 10 days reduced UalbV and FCalb in nephrotic rats fed either LP or HP. The similar pattern of changes in urinary albumin excretion in normal and nephrotic rats after dietary protein augmentation suggests that dietary protein may modify UalbV by the same process in both normal and nephrotic animals. The increases in UalbV and GFR resulting from dietary protein augmentation represent parallel but independent processes, since only the proteinuric response is modified by converting enzyme inhibition. Dietary protein restriction and converting enzyme inhibition exert an additive effect to reduce UalbV.

KW - Albuminuria

KW - Angiotensin

KW - Angiotensin converting-enzyme inhibitor

KW - Glomerular filtration rate

KW - Passive heymann nephritis

UR - http://www.scopus.com/inward/record.url?scp=0025013031&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025013031&partnerID=8YFLogxK

M3 - Article

C2 - 2301589

AN - SCOPUS:0025013031

VL - 258

JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

SN - 1931-857X

IS - 1 27-1

ER -