Differential responsiveness of vascular endothelial cells to different types of fluid mechanical shear stress

Abdul I. Barakat, Deborah Lieu

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

Early atherosclerotic lesions localize preferentially in arterial regions exposed to low flow, oscillatory flow, or both; however, the cellular basis of this observation remains to be determined. Atherogenesis involves dysfunction of the vascular endothelium, the cellular monolayer lining the inner surfaces of blood vessels. How low flow, oscillatory flow, or both may lead to endothelial dysfunction remains unknown. Over the past two decades, fluid mechanical shear (or frictional) stress has been shown to intricately regulate the structure and function of vascular endothelial cells (ECs). Furthermore, recent data indicate that beyond being merely responsive to shear stress, ECs are able to distinguish among and respond differently to different types of shear stress. This review focuses on EC differential responses to different types of steady and unsteady shear stress and discusses the implications of these responses for the localization of early atherosclerotic lesions. The mechanisms by which endothelial differential responsiveness to different types of flow may occur are also discussed.

Original languageEnglish (US)
Pages (from-to)323-343
Number of pages21
JournalCell Biochemistry and Biophysics
Volume38
Issue number3
DOIs
StatePublished - Jun 2003

Keywords

  • Atherosclerosis
  • Endothelium
  • Hemodynamics
  • Mechanotransduction
  • Shear stress

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Biophysics

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