Differential requirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 Semaphorins

Avraham Yaron, Pei Hsin Huang, Hwai-Jong Cheng, Marc Tessier-Lavigne

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

The class 3 Semaphorins Sema3A and Sema3F are potent axonal repellents that cause repulsion by binding Neuropilin-1 and Neuropilin-2, respectively. Plexins are implicated as signaling coreceptors for the Neuropilins, but the identity of the Plexins that transduce Sema3A and Sema3F responses in vivo is uncertain. Here, we show that Plexin-A3 and -A4 are key determinants of these responses, through analysis of a Plexin-A3/Plexin-A4 double mutant mouse. Sensory and sympathetic neurons from the double mutant are insensitive to Sema3A and Sema3F in vitro, and defects in axonal projections in vivo correspond to those seen in Neuropilin-1 and -2 mutants. Interestingly, we found a differential requirement for these two Plexins: signaling via Neuropilin-1 is mediated principally by Plexin-A4, whereas signaling via Neuropilin-2 is mediated principally by Plexin-A3. Thus, Plexin-A3 and -A4 contribute to the specificity of axonal responses to class 3 Semaphorins.

Original languageEnglish (US)
Pages (from-to)513-523
Number of pages11
JournalNeuron
Volume45
Issue number4
DOIs
StatePublished - Feb 17 2005

Fingerprint

Semaphorins
Sensory Receptor Cells
Neuropilin-2
Semaphorin-3A
Neuropilin-1
Neuropilins
plexin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Differential requirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 Semaphorins. / Yaron, Avraham; Huang, Pei Hsin; Cheng, Hwai-Jong; Tessier-Lavigne, Marc.

In: Neuron, Vol. 45, No. 4, 17.02.2005, p. 513-523.

Research output: Contribution to journalArticle

Yaron, Avraham ; Huang, Pei Hsin ; Cheng, Hwai-Jong ; Tessier-Lavigne, Marc. / Differential requirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 Semaphorins. In: Neuron. 2005 ; Vol. 45, No. 4. pp. 513-523.
@article{88adec06f97e4f00a85aeeb92916f54b,
title = "Differential requirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 Semaphorins",
abstract = "The class 3 Semaphorins Sema3A and Sema3F are potent axonal repellents that cause repulsion by binding Neuropilin-1 and Neuropilin-2, respectively. Plexins are implicated as signaling coreceptors for the Neuropilins, but the identity of the Plexins that transduce Sema3A and Sema3F responses in vivo is uncertain. Here, we show that Plexin-A3 and -A4 are key determinants of these responses, through analysis of a Plexin-A3/Plexin-A4 double mutant mouse. Sensory and sympathetic neurons from the double mutant are insensitive to Sema3A and Sema3F in vitro, and defects in axonal projections in vivo correspond to those seen in Neuropilin-1 and -2 mutants. Interestingly, we found a differential requirement for these two Plexins: signaling via Neuropilin-1 is mediated principally by Plexin-A4, whereas signaling via Neuropilin-2 is mediated principally by Plexin-A3. Thus, Plexin-A3 and -A4 contribute to the specificity of axonal responses to class 3 Semaphorins.",
author = "Avraham Yaron and Huang, {Pei Hsin} and Hwai-Jong Cheng and Marc Tessier-Lavigne",
year = "2005",
month = "2",
day = "17",
doi = "10.1016/j.neuron.2005.01.013",
language = "English (US)",
volume = "45",
pages = "513--523",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "4",

}

TY - JOUR

T1 - Differential requirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 Semaphorins

AU - Yaron, Avraham

AU - Huang, Pei Hsin

AU - Cheng, Hwai-Jong

AU - Tessier-Lavigne, Marc

PY - 2005/2/17

Y1 - 2005/2/17

N2 - The class 3 Semaphorins Sema3A and Sema3F are potent axonal repellents that cause repulsion by binding Neuropilin-1 and Neuropilin-2, respectively. Plexins are implicated as signaling coreceptors for the Neuropilins, but the identity of the Plexins that transduce Sema3A and Sema3F responses in vivo is uncertain. Here, we show that Plexin-A3 and -A4 are key determinants of these responses, through analysis of a Plexin-A3/Plexin-A4 double mutant mouse. Sensory and sympathetic neurons from the double mutant are insensitive to Sema3A and Sema3F in vitro, and defects in axonal projections in vivo correspond to those seen in Neuropilin-1 and -2 mutants. Interestingly, we found a differential requirement for these two Plexins: signaling via Neuropilin-1 is mediated principally by Plexin-A4, whereas signaling via Neuropilin-2 is mediated principally by Plexin-A3. Thus, Plexin-A3 and -A4 contribute to the specificity of axonal responses to class 3 Semaphorins.

AB - The class 3 Semaphorins Sema3A and Sema3F are potent axonal repellents that cause repulsion by binding Neuropilin-1 and Neuropilin-2, respectively. Plexins are implicated as signaling coreceptors for the Neuropilins, but the identity of the Plexins that transduce Sema3A and Sema3F responses in vivo is uncertain. Here, we show that Plexin-A3 and -A4 are key determinants of these responses, through analysis of a Plexin-A3/Plexin-A4 double mutant mouse. Sensory and sympathetic neurons from the double mutant are insensitive to Sema3A and Sema3F in vitro, and defects in axonal projections in vivo correspond to those seen in Neuropilin-1 and -2 mutants. Interestingly, we found a differential requirement for these two Plexins: signaling via Neuropilin-1 is mediated principally by Plexin-A4, whereas signaling via Neuropilin-2 is mediated principally by Plexin-A3. Thus, Plexin-A3 and -A4 contribute to the specificity of axonal responses to class 3 Semaphorins.

UR - http://www.scopus.com/inward/record.url?scp=13844276582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13844276582&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2005.01.013

DO - 10.1016/j.neuron.2005.01.013

M3 - Article

VL - 45

SP - 513

EP - 523

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 4

ER -