Differential regulation of the expression of cytokine-induced neutrophil chemoattractant by mouse macrophages

Tawni L. Crippen, David W H Riches, Dallas M. Hyde

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The production of cytokine-induced neutrophil chemoattractant (CINC) by functionally diverse mouse bone-marrow-derived macrophages was determined. Studies showed that β1,3-glucan, IL-1β, TNFα and IFNγ/TNFα induced expression and production of CINC in macrophages while neither IFNγ nor TGFβ alone induced detectable CINC expression. Pretreatment or simultaneous treatment of macrophages with TGFβ resulted in suppression of CINC protein production. These studies demonstrate that IFNγ and TNFα, found early during the inflammatory response, induce production of CINC, as well as induce macrophages into a cytocidal state that are capable of killing transformed cells, parasites and bacteria, and recruiting neutrophils. In contrast, TGFβ, found during reparative stages of the inflammatory response, suppressed production of CINC, while inducing the development of inflammatory macrophages that are capable of producing lysosomal enzymes, enhanced endocytosis and ingestion of particulate matter and function to scavenge debris, debride tissue and stimulate repair.

Original languageEnglish (US)
Pages (from-to)24-32
Number of pages9
JournalPathobiology
Volume66
Issue number1
DOIs
StatePublished - 1998

Fingerprint

Macrophages
Chemotactic Factors
Neutrophils
Cytokines
Particulate Matter
Glucans
Interleukin-1
Debris
Endocytosis
Bacteria
Bone
Repair
Parasites
Tissue
Eating
Enzymes
Proteins

Keywords

  • Bone marrow macrophages
  • C-X-C chemokine
  • Cytokine-induced neutrophil chemoattractant
  • Macrophages
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Biochemistry
  • Immunology and Allergy
  • Cell Biology

Cite this

Differential regulation of the expression of cytokine-induced neutrophil chemoattractant by mouse macrophages. / Crippen, Tawni L.; Riches, David W H; Hyde, Dallas M.

In: Pathobiology, Vol. 66, No. 1, 1998, p. 24-32.

Research output: Contribution to journalArticle

Crippen, Tawni L. ; Riches, David W H ; Hyde, Dallas M. / Differential regulation of the expression of cytokine-induced neutrophil chemoattractant by mouse macrophages. In: Pathobiology. 1998 ; Vol. 66, No. 1. pp. 24-32.
@article{2da270dce03e43618b2b0c4445265088,
title = "Differential regulation of the expression of cytokine-induced neutrophil chemoattractant by mouse macrophages",
abstract = "The production of cytokine-induced neutrophil chemoattractant (CINC) by functionally diverse mouse bone-marrow-derived macrophages was determined. Studies showed that β1,3-glucan, IL-1β, TNFα and IFNγ/TNFα induced expression and production of CINC in macrophages while neither IFNγ nor TGFβ alone induced detectable CINC expression. Pretreatment or simultaneous treatment of macrophages with TGFβ resulted in suppression of CINC protein production. These studies demonstrate that IFNγ and TNFα, found early during the inflammatory response, induce production of CINC, as well as induce macrophages into a cytocidal state that are capable of killing transformed cells, parasites and bacteria, and recruiting neutrophils. In contrast, TGFβ, found during reparative stages of the inflammatory response, suppressed production of CINC, while inducing the development of inflammatory macrophages that are capable of producing lysosomal enzymes, enhanced endocytosis and ingestion of particulate matter and function to scavenge debris, debride tissue and stimulate repair.",
keywords = "Bone marrow macrophages, C-X-C chemokine, Cytokine-induced neutrophil chemoattractant, Macrophages, Transforming growth factor-β",
author = "Crippen, {Tawni L.} and Riches, {David W H} and Hyde, {Dallas M.}",
year = "1998",
doi = "10.1159/000027991",
language = "English (US)",
volume = "66",
pages = "24--32",
journal = "Pathobiology",
issn = "1015-2008",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Differential regulation of the expression of cytokine-induced neutrophil chemoattractant by mouse macrophages

AU - Crippen, Tawni L.

AU - Riches, David W H

AU - Hyde, Dallas M.

PY - 1998

Y1 - 1998

N2 - The production of cytokine-induced neutrophil chemoattractant (CINC) by functionally diverse mouse bone-marrow-derived macrophages was determined. Studies showed that β1,3-glucan, IL-1β, TNFα and IFNγ/TNFα induced expression and production of CINC in macrophages while neither IFNγ nor TGFβ alone induced detectable CINC expression. Pretreatment or simultaneous treatment of macrophages with TGFβ resulted in suppression of CINC protein production. These studies demonstrate that IFNγ and TNFα, found early during the inflammatory response, induce production of CINC, as well as induce macrophages into a cytocidal state that are capable of killing transformed cells, parasites and bacteria, and recruiting neutrophils. In contrast, TGFβ, found during reparative stages of the inflammatory response, suppressed production of CINC, while inducing the development of inflammatory macrophages that are capable of producing lysosomal enzymes, enhanced endocytosis and ingestion of particulate matter and function to scavenge debris, debride tissue and stimulate repair.

AB - The production of cytokine-induced neutrophil chemoattractant (CINC) by functionally diverse mouse bone-marrow-derived macrophages was determined. Studies showed that β1,3-glucan, IL-1β, TNFα and IFNγ/TNFα induced expression and production of CINC in macrophages while neither IFNγ nor TGFβ alone induced detectable CINC expression. Pretreatment or simultaneous treatment of macrophages with TGFβ resulted in suppression of CINC protein production. These studies demonstrate that IFNγ and TNFα, found early during the inflammatory response, induce production of CINC, as well as induce macrophages into a cytocidal state that are capable of killing transformed cells, parasites and bacteria, and recruiting neutrophils. In contrast, TGFβ, found during reparative stages of the inflammatory response, suppressed production of CINC, while inducing the development of inflammatory macrophages that are capable of producing lysosomal enzymes, enhanced endocytosis and ingestion of particulate matter and function to scavenge debris, debride tissue and stimulate repair.

KW - Bone marrow macrophages

KW - C-X-C chemokine

KW - Cytokine-induced neutrophil chemoattractant

KW - Macrophages

KW - Transforming growth factor-β

UR - http://www.scopus.com/inward/record.url?scp=0031911156&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031911156&partnerID=8YFLogxK

U2 - 10.1159/000027991

DO - 10.1159/000027991

M3 - Article

VL - 66

SP - 24

EP - 32

JO - Pathobiology

JF - Pathobiology

SN - 1015-2008

IS - 1

ER -