Differential regulation of the expression of cytokine-induced neutrophil chemoattractant by mouse macrophages

Tawni L. Crippen, David W H Riches, Dallas M. Hyde

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The production of cytokine-induced neutrophil chemoattractant (CINC) by functionally diverse mouse bone-marrow-derived macrophages was determined. Studies showed that β1,3-glucan, IL-1β, TNFα and IFNγ/TNFα induced expression and production of CINC in macrophages while neither IFNγ nor TGFβ alone induced detectable CINC expression. Pretreatment or simultaneous treatment of macrophages with TGFβ resulted in suppression of CINC protein production. These studies demonstrate that IFNγ and TNFα, found early during the inflammatory response, induce production of CINC, as well as induce macrophages into a cytocidal state that are capable of killing transformed cells, parasites and bacteria, and recruiting neutrophils. In contrast, TGFβ, found during reparative stages of the inflammatory response, suppressed production of CINC, while inducing the development of inflammatory macrophages that are capable of producing lysosomal enzymes, enhanced endocytosis and ingestion of particulate matter and function to scavenge debris, debride tissue and stimulate repair.

Original languageEnglish (US)
Pages (from-to)24-32
Number of pages9
JournalPathobiology
Volume66
Issue number1
DOIs
StatePublished - 1998

Keywords

  • Bone marrow macrophages
  • C-X-C chemokine
  • Cytokine-induced neutrophil chemoattractant
  • Macrophages
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Biochemistry
  • Immunology and Allergy
  • Cell Biology

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