Differential pathogenicity of SHIVSF162 P4 infection in pig-tailed and rhesus macaques

Patricia Polacino, Kay Larsen, Lindsey Galmin, John Suschak, Zane Kraft, Leonidas Stamatatos, David Anderson, Susan W. Barnett, Ranajit Pal, Kristen Bost, A. H. Bandivdekar, Chris J Miller, Shiu Lok Hu

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Background: Differential pathogenicity has been observed in cynomolgus and rhesus macaques following primate lentivirus infection. However, little is known about the comparative susceptibility of pig-tailed macaques to lentivirus infection and diseases. Methods: We compared thein vivo infectivity and pathogenicity of a CCR5-tropic SHIVSF162 P4 after intravenous, intravaginal or intrarectal inoculation in rhesus and pig-tailed macaques. Plasma viral load, peripheral blood CD4+ T cell counts and clinical signs were monitored. Results: Both rhesus and pig-tailed macaques are similarly susceptible to SHIVSF162 P4 infection by intravenous and mucosal routes. However, infection was significantly more robust in pig-tailed macaques than in rhesus, resulting in persistent viremia in 9/21 pig-tails vs. 2/24 rhesus (P < 0.013) and severe CD4+ T-cell depletion in 2/21 pig-tails (vs. none in rhesus). Conclusions: Together with earlier observations, our findings underscore the importance of considering host genetic and immunological factors when comparing vaccine efficacy in different macaque species.

Original languageEnglish (US)
Pages (from-to)13-23
Number of pages11
JournalJournal of Medical Primatology
Issue numberSUPPL. 2
StatePublished - 2008


  • AIDS vaccine
  • Intrarectal
  • Intravaginal
  • Intravenous
  • Plasma viremia

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)


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