Abstract
Background: Differential pathogenicity has been observed in cynomolgus and rhesus macaques following primate lentivirus infection. However, little is known about the comparative susceptibility of pig-tailed macaques to lentivirus infection and diseases. Methods: We compared thein vivo infectivity and pathogenicity of a CCR5-tropic SHIVSF162 P4 after intravenous, intravaginal or intrarectal inoculation in rhesus and pig-tailed macaques. Plasma viral load, peripheral blood CD4+ T cell counts and clinical signs were monitored. Results: Both rhesus and pig-tailed macaques are similarly susceptible to SHIVSF162 P4 infection by intravenous and mucosal routes. However, infection was significantly more robust in pig-tailed macaques than in rhesus, resulting in persistent viremia in 9/21 pig-tails vs. 2/24 rhesus (P < 0.013) and severe CD4+ T-cell depletion in 2/21 pig-tails (vs. none in rhesus). Conclusions: Together with earlier observations, our findings underscore the importance of considering host genetic and immunological factors when comparing vaccine efficacy in different macaque species.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 13-23 |
| Number of pages | 11 |
| Journal | Journal of Medical Primatology |
| Volume | 37 |
| Issue number | SUPPL. 2 |
| DOIs | |
| State | Published - 2008 |
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Keywords
- AIDS vaccine
- Intrarectal
- Intravaginal
- Intravenous
- Plasma viremia
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
Differential pathogenicity of SHIVSF162 P4 infection in pig-tailed and rhesus macaques. / Polacino, Patricia; Larsen, Kay; Galmin, Lindsey; Suschak, John; Kraft, Zane; Stamatatos, Leonidas; Anderson, David; Barnett, Susan W.; Pal, Ranajit; Bost, Kristen; Bandivdekar, A. H.; Miller, Chris J; Hu, Shiu Lok.
In: Journal of Medical Primatology, Vol. 37, No. SUPPL. 2, 2008, p. 13-23.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differential pathogenicity of SHIVSF162 P4 infection in pig-tailed and rhesus macaques
AU - Polacino, Patricia
AU - Larsen, Kay
AU - Galmin, Lindsey
AU - Suschak, John
AU - Kraft, Zane
AU - Stamatatos, Leonidas
AU - Anderson, David
AU - Barnett, Susan W.
AU - Pal, Ranajit
AU - Bost, Kristen
AU - Bandivdekar, A. H.
AU - Miller, Chris J
AU - Hu, Shiu Lok
PY - 2008
Y1 - 2008
N2 - Background: Differential pathogenicity has been observed in cynomolgus and rhesus macaques following primate lentivirus infection. However, little is known about the comparative susceptibility of pig-tailed macaques to lentivirus infection and diseases. Methods: We compared thein vivo infectivity and pathogenicity of a CCR5-tropic SHIVSF162 P4 after intravenous, intravaginal or intrarectal inoculation in rhesus and pig-tailed macaques. Plasma viral load, peripheral blood CD4+ T cell counts and clinical signs were monitored. Results: Both rhesus and pig-tailed macaques are similarly susceptible to SHIVSF162 P4 infection by intravenous and mucosal routes. However, infection was significantly more robust in pig-tailed macaques than in rhesus, resulting in persistent viremia in 9/21 pig-tails vs. 2/24 rhesus (P < 0.013) and severe CD4+ T-cell depletion in 2/21 pig-tails (vs. none in rhesus). Conclusions: Together with earlier observations, our findings underscore the importance of considering host genetic and immunological factors when comparing vaccine efficacy in different macaque species.
AB - Background: Differential pathogenicity has been observed in cynomolgus and rhesus macaques following primate lentivirus infection. However, little is known about the comparative susceptibility of pig-tailed macaques to lentivirus infection and diseases. Methods: We compared thein vivo infectivity and pathogenicity of a CCR5-tropic SHIVSF162 P4 after intravenous, intravaginal or intrarectal inoculation in rhesus and pig-tailed macaques. Plasma viral load, peripheral blood CD4+ T cell counts and clinical signs were monitored. Results: Both rhesus and pig-tailed macaques are similarly susceptible to SHIVSF162 P4 infection by intravenous and mucosal routes. However, infection was significantly more robust in pig-tailed macaques than in rhesus, resulting in persistent viremia in 9/21 pig-tails vs. 2/24 rhesus (P < 0.013) and severe CD4+ T-cell depletion in 2/21 pig-tails (vs. none in rhesus). Conclusions: Together with earlier observations, our findings underscore the importance of considering host genetic and immunological factors when comparing vaccine efficacy in different macaque species.
KW - AIDS vaccine
KW - Intrarectal
KW - Intravaginal
KW - Intravenous
KW - Plasma viremia
UR - http://www.scopus.com/inward/record.url?scp=59149101887&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=59149101887&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0684.2008.00325.x
DO - 10.1111/j.1600-0684.2008.00325.x
M3 - Article
C2 - 19187427
AN - SCOPUS:59149101887
VL - 37
SP - 13
EP - 23
JO - Journal of Medical Primatology
JF - Journal of Medical Primatology
SN - 0047-2565
IS - SUPPL. 2
ER -