Differential pathogenicity of SHIVSF162 P4 infection in pig-tailed and rhesus macaques

Patricia Polacino, Kay Larsen, Lindsey Galmin, John Suschak, Zane Kraft, Leonidas Stamatatos, David Anderson, Susan W. Barnett, Ranajit Pal, Kristen Bost, A. H. Bandivdekar, Chris J Miller, Shiu Lok Hu

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Differential pathogenicity has been observed in cynomolgus and rhesus macaques following primate lentivirus infection. However, little is known about the comparative susceptibility of pig-tailed macaques to lentivirus infection and diseases. Methods: We compared thein vivo infectivity and pathogenicity of a CCR5-tropic SHIVSF162 P4 after intravenous, intravaginal or intrarectal inoculation in rhesus and pig-tailed macaques. Plasma viral load, peripheral blood CD4+ T cell counts and clinical signs were monitored. Results: Both rhesus and pig-tailed macaques are similarly susceptible to SHIVSF162 P4 infection by intravenous and mucosal routes. However, infection was significantly more robust in pig-tailed macaques than in rhesus, resulting in persistent viremia in 9/21 pig-tails vs. 2/24 rhesus (P < 0.013) and severe CD4+ T-cell depletion in 2/21 pig-tails (vs. none in rhesus). Conclusions: Together with earlier observations, our findings underscore the importance of considering host genetic and immunological factors when comparing vaccine efficacy in different macaque species.

Original languageEnglish (US)
Pages (from-to)13-23
Number of pages11
JournalJournal of Medical Primatology
Volume37
Issue numberSUPPL. 2
DOIs
StatePublished - 2008

Fingerprint

Macaca nemestrina
Macaca mulatta
Virulence
Swine
pathogenicity
Macaca
Lentivirus
Lentivirus Infections
Infection
infection
tail
T-lymphocytes
immunologic factors
swine
Tail
Macaca fascicularis
viremia
Primate Lentiviruses
viral load
T-Lymphocytes

Keywords

  • AIDS vaccine
  • Intrarectal
  • Intravaginal
  • Intravenous
  • Plasma viremia

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Polacino, P., Larsen, K., Galmin, L., Suschak, J., Kraft, Z., Stamatatos, L., ... Hu, S. L. (2008). Differential pathogenicity of SHIVSF162 P4 infection in pig-tailed and rhesus macaques. Journal of Medical Primatology, 37(SUPPL. 2), 13-23. https://doi.org/10.1111/j.1600-0684.2008.00325.x

Differential pathogenicity of SHIVSF162 P4 infection in pig-tailed and rhesus macaques. / Polacino, Patricia; Larsen, Kay; Galmin, Lindsey; Suschak, John; Kraft, Zane; Stamatatos, Leonidas; Anderson, David; Barnett, Susan W.; Pal, Ranajit; Bost, Kristen; Bandivdekar, A. H.; Miller, Chris J; Hu, Shiu Lok.

In: Journal of Medical Primatology, Vol. 37, No. SUPPL. 2, 2008, p. 13-23.

Research output: Contribution to journalArticle

Polacino, P, Larsen, K, Galmin, L, Suschak, J, Kraft, Z, Stamatatos, L, Anderson, D, Barnett, SW, Pal, R, Bost, K, Bandivdekar, AH, Miller, CJ & Hu, SL 2008, 'Differential pathogenicity of SHIVSF162 P4 infection in pig-tailed and rhesus macaques', Journal of Medical Primatology, vol. 37, no. SUPPL. 2, pp. 13-23. https://doi.org/10.1111/j.1600-0684.2008.00325.x
Polacino, Patricia ; Larsen, Kay ; Galmin, Lindsey ; Suschak, John ; Kraft, Zane ; Stamatatos, Leonidas ; Anderson, David ; Barnett, Susan W. ; Pal, Ranajit ; Bost, Kristen ; Bandivdekar, A. H. ; Miller, Chris J ; Hu, Shiu Lok. / Differential pathogenicity of SHIVSF162 P4 infection in pig-tailed and rhesus macaques. In: Journal of Medical Primatology. 2008 ; Vol. 37, No. SUPPL. 2. pp. 13-23.
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