Abstract
Background: Differential pathogenicity has been observed in cynomolgus and rhesus macaques following primate lentivirus infection. However, little is known about the comparative susceptibility of pig-tailed macaques to lentivirus infection and diseases. Methods: We compared thein vivo infectivity and pathogenicity of a CCR5-tropic SHIVSF162 P4 after intravenous, intravaginal or intrarectal inoculation in rhesus and pig-tailed macaques. Plasma viral load, peripheral blood CD4+ T cell counts and clinical signs were monitored. Results: Both rhesus and pig-tailed macaques are similarly susceptible to SHIVSF162 P4 infection by intravenous and mucosal routes. However, infection was significantly more robust in pig-tailed macaques than in rhesus, resulting in persistent viremia in 9/21 pig-tails vs. 2/24 rhesus (P < 0.013) and severe CD4+ T-cell depletion in 2/21 pig-tails (vs. none in rhesus). Conclusions: Together with earlier observations, our findings underscore the importance of considering host genetic and immunological factors when comparing vaccine efficacy in different macaque species.
Original language | English (US) |
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Pages (from-to) | 13-23 |
Number of pages | 11 |
Journal | Journal of Medical Primatology |
Volume | 37 |
Issue number | SUPPL. 2 |
DOIs | |
State | Published - 2008 |
Keywords
- AIDS vaccine
- Intrarectal
- Intravaginal
- Intravenous
- Plasma viremia
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)