Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats

Christophe Morisseau, Maher Derbel, Terry R. Lane, Donald Stoutamire, Bruce D. Hammock

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Racemic fenvaleric acid [2-(4-chlorophenyl)-3-methyl-butanoic acid], the principal metabolite of fenvalerate, was administrated orally at 0.75, 1.5, and 3.0 mmol/kg body weight/day to Fisher-344 male rats for 7 days. Both pure enantiomers of fenvaleric acid were administered at 1.5 mmol/kg body weight/day; the clofibric acid at the same concentration was used as a positive control. Hepatic enzyme activities were measured. Results obtained clearly show that fenvaleric acid induced numerous hepatic drug metabolism enzymes in F344 rats. The (R) enantiomer of this compound induces a proliferation of peroxisomes, whereas the (S) enantiomer induces CYP2B and mEH activities. Therefore, high exposure to pyrethroid insecticides could interact with the normal metabolism of drugs or xenobiotics.

Original languageEnglish (US)
Pages (from-to)148-153
Number of pages6
JournalToxicological Sciences
Volume52
Issue number2
StatePublished - 1999

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Keywords

  • Drug metabolism
  • Fenvaleric acid
  • Hepatic enzymes
  • Pyrethroids

ASJC Scopus subject areas

  • Toxicology

Cite this

Morisseau, C., Derbel, M., Lane, T. R., Stoutamire, D., & Hammock, B. D. (1999). Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats. Toxicological Sciences, 52(2), 148-153.