Abstract
Racemic fenvaleric acid [2-(4-chlorophenyl)-3-methyl-butanoic acid], the principal metabolite of fenvalerate, was administrated orally at 0.75, 1.5, and 3.0 mmol/kg body weight/day to Fisher-344 male rats for 7 days. Both pure enantiomers of fenvaleric acid were administered at 1.5 mmol/kg body weight/day; the clofibric acid at the same concentration was used as a positive control. Hepatic enzyme activities were measured. Results obtained clearly show that fenvaleric acid induced numerous hepatic drug metabolism enzymes in F344 rats. The (R) enantiomer of this compound induces a proliferation of peroxisomes, whereas the (S) enantiomer induces CYP2B and mEH activities. Therefore, high exposure to pyrethroid insecticides could interact with the normal metabolism of drugs or xenobiotics.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 148-153 |
| Number of pages | 6 |
| Journal | Toxicological Sciences |
| Volume | 52 |
| Issue number | 2 |
| State | Published - 1999 |
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Keywords
- Drug metabolism
- Fenvaleric acid
- Hepatic enzymes
- Pyrethroids
ASJC Scopus subject areas
- Toxicology
Cite this
Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats. / Morisseau, Christophe; Derbel, Maher; Lane, Terry R.; Stoutamire, Donald; Hammock, Bruce D.
In: Toxicological Sciences, Vol. 52, No. 2, 1999, p. 148-153.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats
AU - Morisseau, Christophe
AU - Derbel, Maher
AU - Lane, Terry R.
AU - Stoutamire, Donald
AU - Hammock, Bruce D.
PY - 1999
Y1 - 1999
N2 - Racemic fenvaleric acid [2-(4-chlorophenyl)-3-methyl-butanoic acid], the principal metabolite of fenvalerate, was administrated orally at 0.75, 1.5, and 3.0 mmol/kg body weight/day to Fisher-344 male rats for 7 days. Both pure enantiomers of fenvaleric acid were administered at 1.5 mmol/kg body weight/day; the clofibric acid at the same concentration was used as a positive control. Hepatic enzyme activities were measured. Results obtained clearly show that fenvaleric acid induced numerous hepatic drug metabolism enzymes in F344 rats. The (R) enantiomer of this compound induces a proliferation of peroxisomes, whereas the (S) enantiomer induces CYP2B and mEH activities. Therefore, high exposure to pyrethroid insecticides could interact with the normal metabolism of drugs or xenobiotics.
AB - Racemic fenvaleric acid [2-(4-chlorophenyl)-3-methyl-butanoic acid], the principal metabolite of fenvalerate, was administrated orally at 0.75, 1.5, and 3.0 mmol/kg body weight/day to Fisher-344 male rats for 7 days. Both pure enantiomers of fenvaleric acid were administered at 1.5 mmol/kg body weight/day; the clofibric acid at the same concentration was used as a positive control. Hepatic enzyme activities were measured. Results obtained clearly show that fenvaleric acid induced numerous hepatic drug metabolism enzymes in F344 rats. The (R) enantiomer of this compound induces a proliferation of peroxisomes, whereas the (S) enantiomer induces CYP2B and mEH activities. Therefore, high exposure to pyrethroid insecticides could interact with the normal metabolism of drugs or xenobiotics.
KW - Drug metabolism
KW - Fenvaleric acid
KW - Hepatic enzymes
KW - Pyrethroids
UR - http://www.scopus.com/inward/record.url?scp=0033395988&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033395988&partnerID=8YFLogxK
M3 - Article
C2 - 10630566
AN - SCOPUS:0033395988
VL - 52
SP - 148
EP - 153
JO - Toxicological Sciences
JF - Toxicological Sciences
SN - 1096-6080
IS - 2
ER -