Differential expression of the neu transgene in murine mammary tissues

Kim Deckard-Janatpour, William J. Muller, Lewis A. Chodosh, Heather P. Gardner, Sandra T. Marquis, Robert Coffey, Robert Cardiff

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The mammary glands of control FVB and mice with MTV-LTR promoted transgenes were stained using immunohistochemistry to detect neu expression. Neu expression in the terminal end buds of developing mammary glands and during early pregnancy in FVB mice was confirmed by in situ hybridization. Neu was expressed in all tumors from mice with the neu transgene but not in tumors expressing transforming growth factor α (TGFα) or polyoma virus middle T (PyV-MT). Neu was also expressed sporadically in non-neoplastic mammary cells of transgenic neu mice. However, most mammary cells expressing neu were dysplastic. The differential expression of the neu transgene has important implications for the interpretation of transgenic biology.

Original languageEnglish (US)
Pages (from-to)235-241
Number of pages7
JournalInternational Journal of Oncology
Volume11
Issue number2
StatePublished - Jan 1 1997

Keywords

  • HER- 2/neu (c-erbB-2)
  • Immunohistochemistry
  • Mammary gland
  • Mammary tumor
  • Transgenic mice

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Deckard-Janatpour, K., Muller, W. J., Chodosh, L. A., Gardner, H. P., Marquis, S. T., Coffey, R., & Cardiff, R. (1997). Differential expression of the neu transgene in murine mammary tissues. International Journal of Oncology, 11(2), 235-241.