Differential expression of galectin 3 and galectin 1 in colorectal cancer progression

X. Sanjuan, P. L. Fernandez, A. Castells, V. Castronovo, F. Van den Brule, Fu-Tong Liu, A. Cardesa, E. Campo

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Abstract

Background and Aims: Galectins are β-galactoside-binding proteins possibly involved in tumor progression. The aim of this study was to determine the pattern of galectin 3 and galectin 1 expression and involvement in colorectal cancer progression. Methods: Galectin 3 expression was examined immunohistochemically in 39 samples of normal mucosae, 25 adenomas, 87 carcinomas, and 39 lymph node metastases. Galectin 1 was analyzed in 25 samples of mucosae, 15 adenomas, 25 carcinomas, and 11 metastases. Western blot analysis was also performed. Results: All normal mucosae showed strong nuclear galectin 3 expression, which was down-regulated in the neoplastic progression, because only 60% of adenomas, 48% of carcinomas, and 44% of metastases were strongly positive (P < 0.0001). Cytoplasmic expression was down-regulated in adenomas (16%) but increased again in carcinomas (64%) (P < 0.0001). Galectin 1 expression was mainly detected in stromal cells and correlated with tumor progression from normal mucosae to adenomas and carcinomas (P < 0.0001). Conclusions: Galectin 3 expression is down-regulated in the initial stages of neoplastic progression, whereas a dissociated cytoplasmic expression increases in later phases of tumor progression. Galectin 1 in colorectal mucosa is predominantly a stromal product whose overexpression is associated with the neoplastic progression of colorectal cancer.

Original languageEnglish (US)
Pages (from-to)1906-1915
Number of pages10
JournalGastroenterology
Volume113
Issue number6
StatePublished - 1997
Externally publishedYes

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Galectin 1
Galectin 3
Adenoma
Colorectal Neoplasms
Mucous Membrane
Carcinoma
Neoplasm Metastasis
Galectins
Galactosides
Neoplasms
Stromal Cells
Carrier Proteins
Lymph Nodes
Western Blotting

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Sanjuan, X., Fernandez, P. L., Castells, A., Castronovo, V., Van den Brule, F., Liu, F-T., ... Campo, E. (1997). Differential expression of galectin 3 and galectin 1 in colorectal cancer progression. Gastroenterology, 113(6), 1906-1915.

Differential expression of galectin 3 and galectin 1 in colorectal cancer progression. / Sanjuan, X.; Fernandez, P. L.; Castells, A.; Castronovo, V.; Van den Brule, F.; Liu, Fu-Tong; Cardesa, A.; Campo, E.

In: Gastroenterology, Vol. 113, No. 6, 1997, p. 1906-1915.

Research output: Contribution to journalArticle

Sanjuan, X, Fernandez, PL, Castells, A, Castronovo, V, Van den Brule, F, Liu, F-T, Cardesa, A & Campo, E 1997, 'Differential expression of galectin 3 and galectin 1 in colorectal cancer progression', Gastroenterology, vol. 113, no. 6, pp. 1906-1915.
Sanjuan X, Fernandez PL, Castells A, Castronovo V, Van den Brule F, Liu F-T et al. Differential expression of galectin 3 and galectin 1 in colorectal cancer progression. Gastroenterology. 1997;113(6):1906-1915.
Sanjuan, X. ; Fernandez, P. L. ; Castells, A. ; Castronovo, V. ; Van den Brule, F. ; Liu, Fu-Tong ; Cardesa, A. ; Campo, E. / Differential expression of galectin 3 and galectin 1 in colorectal cancer progression. In: Gastroenterology. 1997 ; Vol. 113, No. 6. pp. 1906-1915.
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AU - Fernandez, P. L.

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AU - Van den Brule, F.

AU - Liu, Fu-Tong

AU - Cardesa, A.

AU - Campo, E.

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AB - Background and Aims: Galectins are β-galactoside-binding proteins possibly involved in tumor progression. The aim of this study was to determine the pattern of galectin 3 and galectin 1 expression and involvement in colorectal cancer progression. Methods: Galectin 3 expression was examined immunohistochemically in 39 samples of normal mucosae, 25 adenomas, 87 carcinomas, and 39 lymph node metastases. Galectin 1 was analyzed in 25 samples of mucosae, 15 adenomas, 25 carcinomas, and 11 metastases. Western blot analysis was also performed. Results: All normal mucosae showed strong nuclear galectin 3 expression, which was down-regulated in the neoplastic progression, because only 60% of adenomas, 48% of carcinomas, and 44% of metastases were strongly positive (P < 0.0001). Cytoplasmic expression was down-regulated in adenomas (16%) but increased again in carcinomas (64%) (P < 0.0001). Galectin 1 expression was mainly detected in stromal cells and correlated with tumor progression from normal mucosae to adenomas and carcinomas (P < 0.0001). Conclusions: Galectin 3 expression is down-regulated in the initial stages of neoplastic progression, whereas a dissociated cytoplasmic expression increases in later phases of tumor progression. Galectin 1 in colorectal mucosa is predominantly a stromal product whose overexpression is associated with the neoplastic progression of colorectal cancer.

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