Abstract
CD40 is a molecule in the tumor necrosis factor receptor/nerve growth factor receptor (TNFR/NGFR) family that is present on both normal and neoplastic B lineage cells. It is also expressed on carcinoma and melanoma cells and can be augmented with interferon γ. CD40 stimulation in normal B cells has been demonstrated to promote normal B cell differentiation and growth in vitro. In contrast to these effects, CD40 stimulation by either anti-CD40 antibodies or a recombinant soluble CD40 ligand can inhibit the growth of human breast carcinomas and aggressive histology B lymphomas in vitro and in vivo. This is believed to occur by activation - induced cell death (AICD) in which stimuli that promote the growth of normal cell types inhibit the growth of neoplastic counterparts. This occurs through the induction of apoptosis, necrosis and/or cell cycle arrest. Thus, CD40 stimulation may be of potential clinical use in the treatment of carcinomas and B cell lymphomas. This review shall provide an overview of the various effects of CD40 stimulation on both normal and neoplastic cell types.
Original language | English (US) |
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Pages (from-to) | 225-233 |
Number of pages | 9 |
Journal | Archivum Immunologiae et Therapiae Experimentalis |
Volume | 48 |
Issue number | 4 |
State | Published - 2000 |
Externally published | Yes |
Keywords
- Apoptosis
- CD40
- Interferon γ
- Lymphoma
- Transformed
ASJC Scopus subject areas
- Immunology