Differential effect of hypoxia on meal size and meal frequency in the rat

D. D. Schnakenberg, P. M.B. Leung, Quinton Rogers

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Abstract

Male rats (n=7, 250 g) were maintained in a vinyl glove box with free access to a 20% casein diet and water. Continuous recording balances (sensitivity 0.1 g) were used to monitor meal feeding behavior during a 3 day preliminary period (P) in air, 1 day of 12% O2 (H) exposure beginning at the onset of the 12 hr dark period, and the first day of recovery (R) in air. Daily water intake was also measured. Food consumption (X ± SEM) during (P), (H), and (R) was 21.5±0.6, 11.6±1.4 and 19.6±0.5 g/day, respectively and the water intake was 31.2±1.6, 10.1±2.3, and 37.1±1.2 ml/day, respectively. Expressed as a percentage of (P), the hypodipsic effect (32.4%) was relatively more severe than the hypophagic effect (54.0%). Postprandial criteria of greater than 10, 20, 30, and 40 min were used to calculate meal size and meal frequency (number of meals). Acute (H) exposure inhibited food consumption by reducing meal size, not meal frequency. However, the size of the first meal during (H) was not reduced. Meal feeding behavior during (R) did not differ from (P). The observed pattern of early termination of a given meal during hypoxia is remarkably similar to that observed during partial water restriction, suggesting that hypoxic hypophagia may, at least in part, be secondary to the hypodipsic effect of hypoxia.

Original languageEnglish (US)
JournalFederation Proceedings
Volume33
Issue number3 I
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Medicine(all)

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