Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases

P. R. Hof, C. Bouras, L. Buée, A. Delacourte, D. P. Perl, John Morrison

Research output: Contribution to journalArticle

151 Scopus citations

Abstract

Head trauma has been associated with the occurrence of Alzhiemer's disease and plays a clear role in the etiopathogenesis of the boxers encephalopathy referred to as dementia pugilistica. Neurofibrillary tangles (NFT), one of the pathological hallmarks of Alzheimer's disease are observed in very high densities in the brains of former professional boxers suffering from dementia pugilistica. In Alzheimer's disease, NFT display striking regional and laminar distribution patterns that have been correlated with the localization of neurons forming specific corticocortical connections. In dementia pugilistica cases, NFT were concentrated in the superficial layers in the neocortex, whereas in Alzheimer's disease they predominated in the deep layers. Thus, the association cortex of brains from dementia pugilistica patients demonstrated an inverse NFT distribution as compared to Alzheimer's disease. This finding suggests that a more circumscribed population of cortical pyramidal neurons might be affected in dementia pugilistica than in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)23-30
Number of pages8
JournalActa Neuropathologica
Volume85
Issue number1
DOIs
StatePublished - Dec 1 1992
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Dementia pugilistica
  • Head trauma
  • Neurofibrillary tangle
  • Tau proteins

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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