Differential diagnosis of clival and spinal tumors

Francisco Vaz-Guimaraes, Griffith R. Harsh

Research output: Chapter in Book/Report/Conference proceedingChapter


Chordomas and chondrosarcomas are distinct pathological entities that share many clinical-radiological similarities. Furthermore, a variety of different tumors may also be a part of their differential diagnosis. These include other primary osseous tumors, cartilaginous, soft tissue, and central nervous system neoplasms as well as congenital, nonneoplastic, and metastatic secondary lesions. Proper management of cranial base and spinal tumors depends, among other factors, on accurate diagnosis. A multidisciplinary team of physicians with significant experience with complex skull base and spinal pathologies should, ideally, evaluate these patients so as to decrease the likelihood of diagnostic errors and treatment delays. This chapter discusses the clinical, radiological, and histological characteristics of cranial base and spinal tumors by which they can be distinguished from chordomas and chondrosarcomas.

Original languageEnglish (US)
Title of host publicationChordomas and Chondrosarcomas of the Skull Base and Spine
PublisherElsevier Inc.
Number of pages14
ISBN (Electronic)9780128043332
ISBN (Print)9780128042571
StatePublished - 2018
Externally publishedYes


  • Chondrosarcoma
  • Chordoma
  • Congenital tumors
  • Differential diagnosis
  • Metastasis
  • Nonneoplastic tumors
  • Primary tumors

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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