Different molecular forms of rat kidney gp330, the dominant autoantigen of active Heymann nephritis

G. G. Jokhadze, A. V. Oleinikov, J. J. Kanalas, Sudesh P Makker

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The primary structure, consisting of 1650 amino acid residues, of the C-terminal end of the dominant autoantigen of active Heymann Nephritis, gp330, from rat kidney was obtained by cloning and sequencing of cDNA clones. Comparison of this sequence with the previously published sequences of fragments of the C-terminal end of gp330 revealed certain differences in their primary structures. These differences included several amino acid substitutions, replacement of a stretch of 15 amino acid residues, and different lengths of cytoplasmic domain (188 versus 213 amino acid residues). These findings of two different primary structures of gp330 provide direct evidence for the existence of two molecular forms of gp330.

Original languageEnglish (US)
Pages (from-to)711-713
Number of pages3
JournalBiochemical Journal
Volume305
Issue number3
StatePublished - 1995

ASJC Scopus subject areas

  • Biochemistry

Fingerprint Dive into the research topics of 'Different molecular forms of rat kidney gp330, the dominant autoantigen of active Heymann nephritis'. Together they form a unique fingerprint.

  • Cite this