Different combinations of gap repressors for common stripes in Anopheles and Drosophila embryos

Yury Goltsev, William Hsiong, Gregory C Lanzaro, Mike Levine

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Drosophila segmentation is governed by a well-defined gene regulation network. The evolution of this network was investigated by examining the expression profiles of a complete set of segmentation genes in the early embryos of the mosquito, Anopheles gambiae. There are numerous differences in the expression profiles as compared with Drosophila. The germline determinant Oskar is expressed in both the anterior and posterior poles of Anopheles embryos but is strictly localized within the posterior plasm of Drosophila. The gap genes hunchback and giant display inverted patterns of expression in posterior regions of Anopheles embryos, while tailless exhibits an expanded pattern as compared with Drosophila. These observations suggest that the segmentation network has undergone considerable evolutionary change in the dipterans and that similar patterns of pair-rule gene expression can be obtained with different combinations of gap repressors. We discuss the evolution of separate stripe enhancers in the eve loci of different dipterans.

Original languageEnglish (US)
Pages (from-to)435-446
Number of pages12
JournalDevelopmental Biology
Volume275
Issue number2
DOIs
StatePublished - Nov 15 2004

Fingerprint

Anopheles
Drosophila
Embryonic Structures
Anopheles gambiae
Gene Regulatory Networks
Culicidae
Genes
Gene Expression

Keywords

  • Diptera
  • Eve
  • Gap genes
  • Oskar
  • Segmentation
  • Stripe enhancers

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Different combinations of gap repressors for common stripes in Anopheles and Drosophila embryos. / Goltsev, Yury; Hsiong, William; Lanzaro, Gregory C; Levine, Mike.

In: Developmental Biology, Vol. 275, No. 2, 15.11.2004, p. 435-446.

Research output: Contribution to journalArticle

Goltsev, Yury ; Hsiong, William ; Lanzaro, Gregory C ; Levine, Mike. / Different combinations of gap repressors for common stripes in Anopheles and Drosophila embryos. In: Developmental Biology. 2004 ; Vol. 275, No. 2. pp. 435-446.
@article{ab1959a9d18f4972a4a8abe1375076e3,
title = "Different combinations of gap repressors for common stripes in Anopheles and Drosophila embryos",
abstract = "Drosophila segmentation is governed by a well-defined gene regulation network. The evolution of this network was investigated by examining the expression profiles of a complete set of segmentation genes in the early embryos of the mosquito, Anopheles gambiae. There are numerous differences in the expression profiles as compared with Drosophila. The germline determinant Oskar is expressed in both the anterior and posterior poles of Anopheles embryos but is strictly localized within the posterior plasm of Drosophila. The gap genes hunchback and giant display inverted patterns of expression in posterior regions of Anopheles embryos, while tailless exhibits an expanded pattern as compared with Drosophila. These observations suggest that the segmentation network has undergone considerable evolutionary change in the dipterans and that similar patterns of pair-rule gene expression can be obtained with different combinations of gap repressors. We discuss the evolution of separate stripe enhancers in the eve loci of different dipterans.",
keywords = "Diptera, Eve, Gap genes, Oskar, Segmentation, Stripe enhancers",
author = "Yury Goltsev and William Hsiong and Lanzaro, {Gregory C} and Mike Levine",
year = "2004",
month = "11",
day = "15",
doi = "10.1016/j.ydbio.2004.08.021",
language = "English (US)",
volume = "275",
pages = "435--446",
journal = "Developmental Biology",
issn = "0012-1606",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Different combinations of gap repressors for common stripes in Anopheles and Drosophila embryos

AU - Goltsev, Yury

AU - Hsiong, William

AU - Lanzaro, Gregory C

AU - Levine, Mike

PY - 2004/11/15

Y1 - 2004/11/15

N2 - Drosophila segmentation is governed by a well-defined gene regulation network. The evolution of this network was investigated by examining the expression profiles of a complete set of segmentation genes in the early embryos of the mosquito, Anopheles gambiae. There are numerous differences in the expression profiles as compared with Drosophila. The germline determinant Oskar is expressed in both the anterior and posterior poles of Anopheles embryos but is strictly localized within the posterior plasm of Drosophila. The gap genes hunchback and giant display inverted patterns of expression in posterior regions of Anopheles embryos, while tailless exhibits an expanded pattern as compared with Drosophila. These observations suggest that the segmentation network has undergone considerable evolutionary change in the dipterans and that similar patterns of pair-rule gene expression can be obtained with different combinations of gap repressors. We discuss the evolution of separate stripe enhancers in the eve loci of different dipterans.

AB - Drosophila segmentation is governed by a well-defined gene regulation network. The evolution of this network was investigated by examining the expression profiles of a complete set of segmentation genes in the early embryos of the mosquito, Anopheles gambiae. There are numerous differences in the expression profiles as compared with Drosophila. The germline determinant Oskar is expressed in both the anterior and posterior poles of Anopheles embryos but is strictly localized within the posterior plasm of Drosophila. The gap genes hunchback and giant display inverted patterns of expression in posterior regions of Anopheles embryos, while tailless exhibits an expanded pattern as compared with Drosophila. These observations suggest that the segmentation network has undergone considerable evolutionary change in the dipterans and that similar patterns of pair-rule gene expression can be obtained with different combinations of gap repressors. We discuss the evolution of separate stripe enhancers in the eve loci of different dipterans.

KW - Diptera

KW - Eve

KW - Gap genes

KW - Oskar

KW - Segmentation

KW - Stripe enhancers

UR - http://www.scopus.com/inward/record.url?scp=14244266753&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14244266753&partnerID=8YFLogxK

U2 - 10.1016/j.ydbio.2004.08.021

DO - 10.1016/j.ydbio.2004.08.021

M3 - Article

VL - 275

SP - 435

EP - 446

JO - Developmental Biology

JF - Developmental Biology

SN - 0012-1606

IS - 2

ER -