Different central and peripheral responses to leptin in rhesus monkeys: Brain transport may be limited

Jon J Ramsey, Joseph W. Kemnitz, Ricki J. Colman, David Cunningham, Andrew G. Swick

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The purpose of this experiment was to determine the effect of leptin administration on food intake and energy expenditure in rhesus monkeys. Four adult male rhesus monkeys, cannulated in the left lateral cerebral ventricle, were used for all phases of this experiment. Food intake was measured following intracerebroventricular injections of vehicle or three doses (500 ng, 2 μg, and 22 μg) leptin. Leptin administration resulted in a dose- dependent decrease in food intake (P < 0.05), with food intake decreased by an average of 54% at 22 μg leptin. Energy expenditure was also measured at two intracerebroventricular doses of leptin. Energy expenditure was not different (P > 0.10) between placebo and leptin injections at either dose. Food intake was also measured following iv injection of 3 mg leptin. In this case, leptin did not alter (P > 0.10) food intake, despite increasing serum leptin levels by as much as 100-fold. These results suggest that leptin is a potent inhibitor of food intake in rhesus monkeys, but this effect requires elevation of leptin concentrations in the cerebrospinal fluid or critical brain sites. The transport system for movement of leptin across the blood- brain barrier may limit the influence of circulating leptin on food intake in monkeys.

Original languageEnglish (US)
Pages (from-to)3230-3235
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume83
Issue number9
DOIs
StatePublished - 1998
Externally publishedYes

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Leptin
Macaca mulatta
Brain
Eating
Injections
Cerebrospinal fluid
Cerebral Ventricles
Lateral Ventricles
Blood-Brain Barrier
Energy Metabolism
Haplorhini
Cerebrospinal Fluid
Experiments
Placebos

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Different central and peripheral responses to leptin in rhesus monkeys : Brain transport may be limited. / Ramsey, Jon J; Kemnitz, Joseph W.; Colman, Ricki J.; Cunningham, David; Swick, Andrew G.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 83, No. 9, 1998, p. 3230-3235.

Research output: Contribution to journalArticle

Ramsey, Jon J ; Kemnitz, Joseph W. ; Colman, Ricki J. ; Cunningham, David ; Swick, Andrew G. / Different central and peripheral responses to leptin in rhesus monkeys : Brain transport may be limited. In: Journal of Clinical Endocrinology and Metabolism. 1998 ; Vol. 83, No. 9. pp. 3230-3235.
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