Different associations of white matter lesions with depression and cognition

Jun Young Lee, Philip Insel, R. S. Mackin, Norbert Schuff, Helena Chui, Charles DeCarli, Kee H. Park, Susanne G. Mueller, Michael W. Weiner

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: To test the hypothesis that white matter lesions (WML) are primarily associated with regional frontal cortical volumes, and to determine the mediating effects of these regional frontal cortices on the associations of WML with depressive symptoms and cognitive dysfunction.Methods: Structural brains MRIs were performed on 161 participants: cognitively normal, cognitive impaired but not demented, and demented participants. Lobar WML volumes, regional frontal cortical volumes, depressive symptom severity, and cognitive abilities were measured. Multiple linear regression analyses were used to identify WML volume effects on frontal cortical volume. Structural equation modeling was used to determine the MRI-depression and the MRI-cognition path relationships.Results: WML predicted frontal cortical volume, particularly in medial orbirtofrontal cortex, irrespective of age, gender, education, and group status. WML directly predicted depressive score, and this relationship was not mediated by regional frontal cortices. In contrast, the association between WML and cognitive function was indirect and mediated by regional frontal cortices.Conclusions: These findings suggest that the neurobiological mechanisms underpinning depressive symptoms and cognitive dysfunction in older adults may differ.

Original languageEnglish (US)
Article number83
JournalBMC Neurology
Volume12
DOIs
StatePublished - Aug 25 2012

Fingerprint

Cognition
Depression
Frontal Lobe
Aptitude
White Matter
Linear Models
Regression Analysis
Education
Brain

Keywords

  • Cognition
  • Depression
  • Frontal lobe
  • Leukoaraiosis
  • Mediation

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Lee, J. Y., Insel, P., Mackin, R. S., Schuff, N., Chui, H., DeCarli, C., ... Weiner, M. W. (2012). Different associations of white matter lesions with depression and cognition. BMC Neurology, 12, [83]. https://doi.org/10.1186/1471-2377-12-83

Different associations of white matter lesions with depression and cognition. / Lee, Jun Young; Insel, Philip; Mackin, R. S.; Schuff, Norbert; Chui, Helena; DeCarli, Charles; Park, Kee H.; Mueller, Susanne G.; Weiner, Michael W.

In: BMC Neurology, Vol. 12, 83, 25.08.2012.

Research output: Contribution to journalArticle

Lee, JY, Insel, P, Mackin, RS, Schuff, N, Chui, H, DeCarli, C, Park, KH, Mueller, SG & Weiner, MW 2012, 'Different associations of white matter lesions with depression and cognition', BMC Neurology, vol. 12, 83. https://doi.org/10.1186/1471-2377-12-83
Lee, Jun Young ; Insel, Philip ; Mackin, R. S. ; Schuff, Norbert ; Chui, Helena ; DeCarli, Charles ; Park, Kee H. ; Mueller, Susanne G. ; Weiner, Michael W. / Different associations of white matter lesions with depression and cognition. In: BMC Neurology. 2012 ; Vol. 12.
@article{57fa7258ce4a4b29beef00bbc59f4f02,
title = "Different associations of white matter lesions with depression and cognition",
abstract = "Background: To test the hypothesis that white matter lesions (WML) are primarily associated with regional frontal cortical volumes, and to determine the mediating effects of these regional frontal cortices on the associations of WML with depressive symptoms and cognitive dysfunction.Methods: Structural brains MRIs were performed on 161 participants: cognitively normal, cognitive impaired but not demented, and demented participants. Lobar WML volumes, regional frontal cortical volumes, depressive symptom severity, and cognitive abilities were measured. Multiple linear regression analyses were used to identify WML volume effects on frontal cortical volume. Structural equation modeling was used to determine the MRI-depression and the MRI-cognition path relationships.Results: WML predicted frontal cortical volume, particularly in medial orbirtofrontal cortex, irrespective of age, gender, education, and group status. WML directly predicted depressive score, and this relationship was not mediated by regional frontal cortices. In contrast, the association between WML and cognitive function was indirect and mediated by regional frontal cortices.Conclusions: These findings suggest that the neurobiological mechanisms underpinning depressive symptoms and cognitive dysfunction in older adults may differ.",
keywords = "Cognition, Depression, Frontal lobe, Leukoaraiosis, Mediation",
author = "Lee, {Jun Young} and Philip Insel and Mackin, {R. S.} and Norbert Schuff and Helena Chui and Charles DeCarli and Park, {Kee H.} and Mueller, {Susanne G.} and Weiner, {Michael W.}",
year = "2012",
month = "8",
day = "25",
doi = "10.1186/1471-2377-12-83",
language = "English (US)",
volume = "12",
journal = "BMC Neurology",
issn = "1471-2377",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Different associations of white matter lesions with depression and cognition

AU - Lee, Jun Young

AU - Insel, Philip

AU - Mackin, R. S.

AU - Schuff, Norbert

AU - Chui, Helena

AU - DeCarli, Charles

AU - Park, Kee H.

AU - Mueller, Susanne G.

AU - Weiner, Michael W.

PY - 2012/8/25

Y1 - 2012/8/25

N2 - Background: To test the hypothesis that white matter lesions (WML) are primarily associated with regional frontal cortical volumes, and to determine the mediating effects of these regional frontal cortices on the associations of WML with depressive symptoms and cognitive dysfunction.Methods: Structural brains MRIs were performed on 161 participants: cognitively normal, cognitive impaired but not demented, and demented participants. Lobar WML volumes, regional frontal cortical volumes, depressive symptom severity, and cognitive abilities were measured. Multiple linear regression analyses were used to identify WML volume effects on frontal cortical volume. Structural equation modeling was used to determine the MRI-depression and the MRI-cognition path relationships.Results: WML predicted frontal cortical volume, particularly in medial orbirtofrontal cortex, irrespective of age, gender, education, and group status. WML directly predicted depressive score, and this relationship was not mediated by regional frontal cortices. In contrast, the association between WML and cognitive function was indirect and mediated by regional frontal cortices.Conclusions: These findings suggest that the neurobiological mechanisms underpinning depressive symptoms and cognitive dysfunction in older adults may differ.

AB - Background: To test the hypothesis that white matter lesions (WML) are primarily associated with regional frontal cortical volumes, and to determine the mediating effects of these regional frontal cortices on the associations of WML with depressive symptoms and cognitive dysfunction.Methods: Structural brains MRIs were performed on 161 participants: cognitively normal, cognitive impaired but not demented, and demented participants. Lobar WML volumes, regional frontal cortical volumes, depressive symptom severity, and cognitive abilities were measured. Multiple linear regression analyses were used to identify WML volume effects on frontal cortical volume. Structural equation modeling was used to determine the MRI-depression and the MRI-cognition path relationships.Results: WML predicted frontal cortical volume, particularly in medial orbirtofrontal cortex, irrespective of age, gender, education, and group status. WML directly predicted depressive score, and this relationship was not mediated by regional frontal cortices. In contrast, the association between WML and cognitive function was indirect and mediated by regional frontal cortices.Conclusions: These findings suggest that the neurobiological mechanisms underpinning depressive symptoms and cognitive dysfunction in older adults may differ.

KW - Cognition

KW - Depression

KW - Frontal lobe

KW - Leukoaraiosis

KW - Mediation

UR - http://www.scopus.com/inward/record.url?scp=84865288373&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865288373&partnerID=8YFLogxK

U2 - 10.1186/1471-2377-12-83

DO - 10.1186/1471-2377-12-83

M3 - Article

C2 - 22920586

AN - SCOPUS:84865288373

VL - 12

JO - BMC Neurology

JF - BMC Neurology

SN - 1471-2377

M1 - 83

ER -