Abstract
We investigated SIV infection and expression of adhesion molecules in the small intestine of rhesus macaques infected with pathogenic SIV (SIVmac) or nonpathogenic clone (SIV1A11). There was a wider dissemination and marked difference in tissue localization of SIVmac relative to SIV1A11. Our results also indicate that viral pathogenicity is associated with increased migration of inflammatory cells expressing VLA-alpha 4, LFA-1 alpha, Mac-1 alpha, ICAM-1, and beta 2 integrin into the intestinal mucosa.
Original language | English (US) |
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Pages (from-to) | 132-140 |
Number of pages | 9 |
Journal | Journal of Medical Primatology |
Volume | 24 |
Issue number | 3 |
State | Published - May 1995 |
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)