Differences in viral distribution and cell adhesion molecule expression in the intestinal tract of rhesus macaques infected with pathogenic and nonpathogenic SIV.

J. D. Stone, C. C. Heise, D. R. Canfield, M. J. Elices, Satya Dandekar

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We investigated SIV infection and expression of adhesion molecules in the small intestine of rhesus macaques infected with pathogenic SIV (SIVmac) or nonpathogenic clone (SIV1A11). There was a wider dissemination and marked difference in tissue localization of SIVmac relative to SIV1A11. Our results also indicate that viral pathogenicity is associated with increased migration of inflammatory cells expressing VLA-alpha 4, LFA-1 alpha, Mac-1 alpha, ICAM-1, and beta 2 integrin into the intestinal mucosa.

Original languageEnglish (US)
Pages (from-to)132-140
Number of pages9
JournalJournal of Medical Primatology
Volume24
Issue number3
StatePublished - May 1995

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Integrin beta Chains
Integrin alpha4beta1
Lymphocyte Function-Associated Antigen-1
integrins
Cell Adhesion Molecules
Intercellular Adhesion Molecule-1
Intestinal Mucosa
intestinal mucosa
Macaca mulatta
cell adhesion
Small Intestine
Cell Movement
Virulence
adhesion
small intestine
intestines
pathogenicity
Clone Cells
clones
Infection

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Differences in viral distribution and cell adhesion molecule expression in the intestinal tract of rhesus macaques infected with pathogenic and nonpathogenic SIV. / Stone, J. D.; Heise, C. C.; Canfield, D. R.; Elices, M. J.; Dandekar, Satya.

In: Journal of Medical Primatology, Vol. 24, No. 3, 05.1995, p. 132-140.

Research output: Contribution to journalArticle

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AU - Elices, M. J.

AU - Dandekar, Satya

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