Abstract
We investigated SIV infection and expression of adhesion molecules in the small intestine of rhesus macaques infected with pathogenic SIV (SIVmac) or nonpathogenic clone (SIV1A11). There was a wider dissemination and marked difference in tissue localization of SIVmac relative to SIV1A11. Our results also indicate that viral pathogenicity is associated with increased migration of inflammatory cells expressing VLA-alpha 4, LFA-1 alpha, Mac-1 alpha, ICAM-1, and beta 2 integrin into the intestinal mucosa.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 132-140 |
| Number of pages | 9 |
| Journal | Journal of Medical Primatology |
| Volume | 24 |
| Issue number | 3 |
| State | Published - May 1995 |
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
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Stone, J. D., Heise, C. C., Canfield, D. R., Elices, M. J., & Dandekar, S. (1995). Differences in viral distribution and cell adhesion molecule expression in the intestinal tract of rhesus macaques infected with pathogenic and nonpathogenic SIV. Journal of Medical Primatology, 24(3), 132-140.