Differences in viral distribution and cell adhesion molecule expression in the intestinal tract of rhesus macaques infected with pathogenic and nonpathogenic SIV.

J. D. Stone, C. C. Heise, D. R. Canfield, M. J. Elices, Satya Dandekar

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We investigated SIV infection and expression of adhesion molecules in the small intestine of rhesus macaques infected with pathogenic SIV (SIVmac) or nonpathogenic clone (SIV1A11). There was a wider dissemination and marked difference in tissue localization of SIVmac relative to SIV1A11. Our results also indicate that viral pathogenicity is associated with increased migration of inflammatory cells expressing VLA-alpha 4, LFA-1 alpha, Mac-1 alpha, ICAM-1, and beta 2 integrin into the intestinal mucosa.

Original languageEnglish (US)
Pages (from-to)132-140
Number of pages9
JournalJournal of Medical Primatology
Volume24
Issue number3
StatePublished - May 1995

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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