Abstract
We investigated SIV infection and expression of adhesion molecules in the small intestine of rhesus macaques infected with pathogenic SIV (SIVmac) or nonpathogenic clone (SIV1A11). There was a wider dissemination and marked difference in tissue localization of SIVmac relative to SIV1A11. Our results also indicate that viral pathogenicity is associated with increased migration of inflammatory cells expressing VLA-alpha 4, LFA-1 alpha, Mac-1 alpha, ICAM-1, and beta 2 integrin into the intestinal mucosa.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 132-140 |
| Number of pages | 9 |
| Journal | Journal of Medical Primatology |
| Volume | 24 |
| Issue number | 3 |
| State | Published - May 1995 |
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ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
Differences in viral distribution and cell adhesion molecule expression in the intestinal tract of rhesus macaques infected with pathogenic and nonpathogenic SIV. / Stone, J. D.; Heise, C. C.; Canfield, D. R.; Elices, M. J.; Dandekar, Satya.
In: Journal of Medical Primatology, Vol. 24, No. 3, 05.1995, p. 132-140.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differences in viral distribution and cell adhesion molecule expression in the intestinal tract of rhesus macaques infected with pathogenic and nonpathogenic SIV.
AU - Stone, J. D.
AU - Heise, C. C.
AU - Canfield, D. R.
AU - Elices, M. J.
AU - Dandekar, Satya
PY - 1995/5
Y1 - 1995/5
N2 - We investigated SIV infection and expression of adhesion molecules in the small intestine of rhesus macaques infected with pathogenic SIV (SIVmac) or nonpathogenic clone (SIV1A11). There was a wider dissemination and marked difference in tissue localization of SIVmac relative to SIV1A11. Our results also indicate that viral pathogenicity is associated with increased migration of inflammatory cells expressing VLA-alpha 4, LFA-1 alpha, Mac-1 alpha, ICAM-1, and beta 2 integrin into the intestinal mucosa.
AB - We investigated SIV infection and expression of adhesion molecules in the small intestine of rhesus macaques infected with pathogenic SIV (SIVmac) or nonpathogenic clone (SIV1A11). There was a wider dissemination and marked difference in tissue localization of SIVmac relative to SIV1A11. Our results also indicate that viral pathogenicity is associated with increased migration of inflammatory cells expressing VLA-alpha 4, LFA-1 alpha, Mac-1 alpha, ICAM-1, and beta 2 integrin into the intestinal mucosa.
UR - http://www.scopus.com/inward/record.url?scp=0029296083&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029296083&partnerID=8YFLogxK
M3 - Article
VL - 24
SP - 132
EP - 140
JO - Journal of Medical Primatology
JF - Journal of Medical Primatology
SN - 0047-2565
IS - 3
ER -