TY - JOUR
T1 - Differences in exon expression and alternatively spliced genes in blood of multiple sclerosis compared to healthy control subjects
AU - Tian, Yingfang
AU - Apperson, Michelle L
AU - Ander, Bradley
AU - Liu, Da
AU - Stomova, Boryana S.
AU - Jickling, Glen C.
AU - Enriquez, Richelle
AU - Agius, Mark A.
AU - Sharp, Frank R
PY - 2011/1
Y1 - 2011/1
N2 - Using whole genome exon microarrays 120 exons were differentially expressed between medication-free multiple sclerosis (MS) subjects in remission and healthy control subjects (HS) (p < 0.001, fold change > |1.2|). These exons differentiated MS from HS using cluster analyses, principal components analyses (PCAs) and cross-validation. In addition, 340 genes (transcripts) were predicted to be alternatively spliced in MS compared to HS. These findings may provide insight into the pathophysiology of MS and potentially provide prognostic and diagnostic biomarkers. However, given that multiple comparisons were performed on a very small sample, these preliminary findings require confirmation using a much larger independent cohort.
AB - Using whole genome exon microarrays 120 exons were differentially expressed between medication-free multiple sclerosis (MS) subjects in remission and healthy control subjects (HS) (p < 0.001, fold change > |1.2|). These exons differentiated MS from HS using cluster analyses, principal components analyses (PCAs) and cross-validation. In addition, 340 genes (transcripts) were predicted to be alternatively spliced in MS compared to HS. These findings may provide insight into the pathophysiology of MS and potentially provide prognostic and diagnostic biomarkers. However, given that multiple comparisons were performed on a very small sample, these preliminary findings require confirmation using a much larger independent cohort.
KW - Alternative splicing
KW - Blood biomarker
KW - Exon expression profiles
KW - Gene expression profiling
KW - Multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=78650975552&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650975552&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2010.09.001
DO - 10.1016/j.jneuroim.2010.09.001
M3 - Article
C2 - 20920832
AN - SCOPUS:78650975552
VL - 230
SP - 124
EP - 129
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -