Differences in clinicopathologic variables between Borrelia C6 antigen seroreactive and Borrelia C6 seronegative glomerulopathy in dogs

Research output: Contribution to journalArticle

Abstract

Background: Rapidly progressive glomerulonephritis has been described in dogs that seroreact to Borrelia burgdorferi, but no studies have compared clinicopathologic differences in Lyme-seroreactive dogs with protein-losing nephropathy (PLN) versus dogs with Borrelia-seronegative PLN. Hypothesis/Objectives: Dogs with Borrelia C6 antigen-seroreactive PLN have distinct clinicopathologic findings when compared to dogs with Borrelia seronegative PLN. Animals: Forty dogs with PLN and Borrelia C6 antigen seroreactivity and 78 C6-seronegative temporally matched dogs with PLN. Methods: Retrospective prevalence case-control study. Clinical information was retrieved from records of dogs examined at the University of California, Davis, Veterinary Medical Teaching Hospital. Histopathologic findings in renal tissue procured by biopsy or necropsy of dogs with PLN were reviewed. Results: Retrievers and retriever mixes were overrepresented in seroreactive dogs (P <.001). Seroreactive dogs were more likely to have thrombocytopenia (P <.001), azotemia (P =.002), hyperphosphatemia (P <.001), anemia (P <.001), and neutrophilia (P =.003). Hematuria, glucosuria, and pyuria despite negative urine culture were more likely in seroreactive dogs (all P ≤.002). Histopathologic findings were consistent with immune-complex glomerulonephritis in 16 of 16 case dogs and 7 of 23 control dogs (P = 006). Prevalence of polyarthritis was not different between groups (P =.17). Conclusions and Clinical Importance: C6 seroreactivity in dogs with PLN is associated with a clinicopathologically distinct syndrome when compared with other types of PLN. Early recognition of this syndrome has the potential to improve outcomes through specific aggressive and early treatment.

Original languageEnglish (US)
JournalJournal of Veterinary Internal Medicine
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

glomerulopathy
Borrelia
Dogs
antigens
Antigens
kidney diseases
dogs
Proteins
proteins
glomerulonephritis
Glomerulonephritis
Pyuria
Hyperphosphatemia
Azotemia
hematuria
antigen-antibody complex
Borrelia burgdorferi
uremia
thrombocytopenia

Keywords

  • glomerulonephritis
  • Lyme disease
  • PLN
  • polyarthritis
  • pyuria
  • thrombocytopenia

ASJC Scopus subject areas

  • veterinary(all)

Cite this

@article{be35e5304efe44b59040a8962725e6d6,
title = "Differences in clinicopathologic variables between Borrelia C6 antigen seroreactive and Borrelia C6 seronegative glomerulopathy in dogs",
abstract = "Background: Rapidly progressive glomerulonephritis has been described in dogs that seroreact to Borrelia burgdorferi, but no studies have compared clinicopathologic differences in Lyme-seroreactive dogs with protein-losing nephropathy (PLN) versus dogs with Borrelia-seronegative PLN. Hypothesis/Objectives: Dogs with Borrelia C6 antigen-seroreactive PLN have distinct clinicopathologic findings when compared to dogs with Borrelia seronegative PLN. Animals: Forty dogs with PLN and Borrelia C6 antigen seroreactivity and 78 C6-seronegative temporally matched dogs with PLN. Methods: Retrospective prevalence case-control study. Clinical information was retrieved from records of dogs examined at the University of California, Davis, Veterinary Medical Teaching Hospital. Histopathologic findings in renal tissue procured by biopsy or necropsy of dogs with PLN were reviewed. Results: Retrievers and retriever mixes were overrepresented in seroreactive dogs (P <.001). Seroreactive dogs were more likely to have thrombocytopenia (P <.001), azotemia (P =.002), hyperphosphatemia (P <.001), anemia (P <.001), and neutrophilia (P =.003). Hematuria, glucosuria, and pyuria despite negative urine culture were more likely in seroreactive dogs (all P ≤.002). Histopathologic findings were consistent with immune-complex glomerulonephritis in 16 of 16 case dogs and 7 of 23 control dogs (P = 006). Prevalence of polyarthritis was not different between groups (P =.17). Conclusions and Clinical Importance: C6 seroreactivity in dogs with PLN is associated with a clinicopathologically distinct syndrome when compared with other types of PLN. Early recognition of this syndrome has the potential to improve outcomes through specific aggressive and early treatment.",
keywords = "glomerulonephritis, Lyme disease, PLN, polyarthritis, pyuria, thrombocytopenia",
author = "Borys, {Moria A.} and Kass, {Philip H.} and Mohr, {Frederick C.} and Sykes, {Jane E.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1111/jvim.15586",
language = "English (US)",
journal = "Journal of Veterinary Internal Medicine",
issn = "0891-6640",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Differences in clinicopathologic variables between Borrelia C6 antigen seroreactive and Borrelia C6 seronegative glomerulopathy in dogs

AU - Borys, Moria A.

AU - Kass, Philip H.

AU - Mohr, Frederick C.

AU - Sykes, Jane E.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Rapidly progressive glomerulonephritis has been described in dogs that seroreact to Borrelia burgdorferi, but no studies have compared clinicopathologic differences in Lyme-seroreactive dogs with protein-losing nephropathy (PLN) versus dogs with Borrelia-seronegative PLN. Hypothesis/Objectives: Dogs with Borrelia C6 antigen-seroreactive PLN have distinct clinicopathologic findings when compared to dogs with Borrelia seronegative PLN. Animals: Forty dogs with PLN and Borrelia C6 antigen seroreactivity and 78 C6-seronegative temporally matched dogs with PLN. Methods: Retrospective prevalence case-control study. Clinical information was retrieved from records of dogs examined at the University of California, Davis, Veterinary Medical Teaching Hospital. Histopathologic findings in renal tissue procured by biopsy or necropsy of dogs with PLN were reviewed. Results: Retrievers and retriever mixes were overrepresented in seroreactive dogs (P <.001). Seroreactive dogs were more likely to have thrombocytopenia (P <.001), azotemia (P =.002), hyperphosphatemia (P <.001), anemia (P <.001), and neutrophilia (P =.003). Hematuria, glucosuria, and pyuria despite negative urine culture were more likely in seroreactive dogs (all P ≤.002). Histopathologic findings were consistent with immune-complex glomerulonephritis in 16 of 16 case dogs and 7 of 23 control dogs (P = 006). Prevalence of polyarthritis was not different between groups (P =.17). Conclusions and Clinical Importance: C6 seroreactivity in dogs with PLN is associated with a clinicopathologically distinct syndrome when compared with other types of PLN. Early recognition of this syndrome has the potential to improve outcomes through specific aggressive and early treatment.

AB - Background: Rapidly progressive glomerulonephritis has been described in dogs that seroreact to Borrelia burgdorferi, but no studies have compared clinicopathologic differences in Lyme-seroreactive dogs with protein-losing nephropathy (PLN) versus dogs with Borrelia-seronegative PLN. Hypothesis/Objectives: Dogs with Borrelia C6 antigen-seroreactive PLN have distinct clinicopathologic findings when compared to dogs with Borrelia seronegative PLN. Animals: Forty dogs with PLN and Borrelia C6 antigen seroreactivity and 78 C6-seronegative temporally matched dogs with PLN. Methods: Retrospective prevalence case-control study. Clinical information was retrieved from records of dogs examined at the University of California, Davis, Veterinary Medical Teaching Hospital. Histopathologic findings in renal tissue procured by biopsy or necropsy of dogs with PLN were reviewed. Results: Retrievers and retriever mixes were overrepresented in seroreactive dogs (P <.001). Seroreactive dogs were more likely to have thrombocytopenia (P <.001), azotemia (P =.002), hyperphosphatemia (P <.001), anemia (P <.001), and neutrophilia (P =.003). Hematuria, glucosuria, and pyuria despite negative urine culture were more likely in seroreactive dogs (all P ≤.002). Histopathologic findings were consistent with immune-complex glomerulonephritis in 16 of 16 case dogs and 7 of 23 control dogs (P = 006). Prevalence of polyarthritis was not different between groups (P =.17). Conclusions and Clinical Importance: C6 seroreactivity in dogs with PLN is associated with a clinicopathologically distinct syndrome when compared with other types of PLN. Early recognition of this syndrome has the potential to improve outcomes through specific aggressive and early treatment.

KW - glomerulonephritis

KW - Lyme disease

KW - PLN

KW - polyarthritis

KW - pyuria

KW - thrombocytopenia

UR - http://www.scopus.com/inward/record.url?scp=85070944965&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070944965&partnerID=8YFLogxK

U2 - 10.1111/jvim.15586

DO - 10.1111/jvim.15586

M3 - Article

C2 - 31444996

AN - SCOPUS:85070944965

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

ER -