Dietary protein restriction and preservation of kidney function in chronic kidney disease

George Kaysen, Golaun Odabaei

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Dietary protein augmentation elicits an increase in single nephron glomerular filtration rate (GFR) and increased transglomerular pressure. This is similar to the hemodynamic response to reduction in renal mass. Among patients and experimental animals with proteinuric renal disease, these changes also cause an increase in glomerular permselectivity, which in experimental animals accelerates loss of renal function. A meta-analysis of a group of prospective randomized trials including over 2,000 patients found a significant effect on reducing dietary protein decreasing the risk of end-stage renal disease or death (defined as renal death). This differs somewhat in the outcomes of clinical trials using intermediate outcomes, such as the Modification of Diet in Renal Disease study that used change in GFR in part because of the initial hemodynamic effect of reduction in GFR mediated by dietary protein restriction.

Original languageEnglish (US)
Pages (from-to)22-25
Number of pages4
JournalBlood Purification
Volume35
Issue number1-3
DOIs
StatePublished - Jan 2013

Fingerprint

Dietary Proteins
Chronic Renal Insufficiency
Kidney
Glomerular Filtration Rate
Hemodynamics
Diet Therapy
Nephrons
Chronic Kidney Failure
Meta-Analysis
Clinical Trials
Pressure

Keywords

  • Endothelin
  • Glomerular pressure
  • Proteinuria
  • Renal acidification

ASJC Scopus subject areas

  • Nephrology
  • Hematology

Cite this

Dietary protein restriction and preservation of kidney function in chronic kidney disease. / Kaysen, George; Odabaei, Golaun.

In: Blood Purification, Vol. 35, No. 1-3, 01.2013, p. 22-25.

Research output: Contribution to journalArticle

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