Dietary polyunsaturated fatty acids decrease anti-dsDNA and anti-cardiolipin antibodies production in idiotype induced mouse model of systemic lupus erythematosus

R. Reifen, M. Blank, A. Afek, Y. Kopilowiz, D. Sklan, M. Eric Gershwin, B. German, S. Yoshida, Y. Shoenfeld

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective: To examine the effect of diets with different polyunsaturated fatty acid contents, including linseed oil which contains 70% omega-3 fatty acids, on autoantibody production in idiotype induced mouse model of systemic lupus erythematosus (SLE). Methods: Five different fats were fed to mice with induced SLE and antibody titers to anti-DNA and anti-cardiolipin were determined and histological examination of kidneys were carried out. Results: SLE mice fed linseed oil showed lower titers of antibodies to DNA and to cardiolipin and less severe kidney damage than mice fed other diets, including fish oil. Conclusion: Use of linseed oil may attenuate the severity of SLE and this diet may be recommended for other auto-immune diseases as well.

Original languageEnglish (US)
Pages (from-to)192-197
Number of pages6
JournalLupus
Volume7
Issue number3
DOIs
StatePublished - 1998

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Cardiolipins
Linseed Oil
Unsaturated Fatty Acids
Systemic Lupus Erythematosus
Antibody Formation
Anti-Idiotypic Antibodies
Diet
Kidney
Fish Oils
Antibodies
DNA
Immune System Diseases
Omega-3 Fatty Acids
Autoantibodies
Fats

Keywords

  • Autoantibodies
  • Autoimmune diseases
  • Lupus erythematosus
  • Nutrition
  • Polyunsaturated fatty acids

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Dietary polyunsaturated fatty acids decrease anti-dsDNA and anti-cardiolipin antibodies production in idiotype induced mouse model of systemic lupus erythematosus. / Reifen, R.; Blank, M.; Afek, A.; Kopilowiz, Y.; Sklan, D.; Gershwin, M. Eric; German, B.; Yoshida, S.; Shoenfeld, Y.

In: Lupus, Vol. 7, No. 3, 1998, p. 192-197.

Research output: Contribution to journalArticle

Reifen, R. ; Blank, M. ; Afek, A. ; Kopilowiz, Y. ; Sklan, D. ; Gershwin, M. Eric ; German, B. ; Yoshida, S. ; Shoenfeld, Y. / Dietary polyunsaturated fatty acids decrease anti-dsDNA and anti-cardiolipin antibodies production in idiotype induced mouse model of systemic lupus erythematosus. In: Lupus. 1998 ; Vol. 7, No. 3. pp. 192-197.
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AU - Reifen, R.

AU - Blank, M.

AU - Afek, A.

AU - Kopilowiz, Y.

AU - Sklan, D.

AU - Gershwin, M. Eric

AU - German, B.

AU - Yoshida, S.

AU - Shoenfeld, Y.

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