Dietary polyunsaturated fatty acids decrease anti-dsDNA and anti-cardiolipin antibodies production in idiotype induced mouse model of systemic lupus erythematosus

R. Reifen, M. Blank, A. Afek, Y. Kopilowiz, D. Sklan, M. Eric Gershwin, B. German, S. Yoshida, Y. Shoenfeld

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Objective: To examine the effect of diets with different polyunsaturated fatty acid contents, including linseed oil which contains 70% omega-3 fatty acids, on autoantibody production in idiotype induced mouse model of systemic lupus erythematosus (SLE). Methods: Five different fats were fed to mice with induced SLE and antibody titers to anti-DNA and anti-cardiolipin were determined and histological examination of kidneys were carried out. Results: SLE mice fed linseed oil showed lower titers of antibodies to DNA and to cardiolipin and less severe kidney damage than mice fed other diets, including fish oil. Conclusion: Use of linseed oil may attenuate the severity of SLE and this diet may be recommended for other auto-immune diseases as well.

Original languageEnglish (US)
Pages (from-to)192-197
Number of pages6
JournalLupus
Volume7
Issue number3
DOIs
StatePublished - 1998

Keywords

  • Autoantibodies
  • Autoimmune diseases
  • Lupus erythematosus
  • Nutrition
  • Polyunsaturated fatty acids

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Fingerprint Dive into the research topics of 'Dietary polyunsaturated fatty acids decrease anti-dsDNA and anti-cardiolipin antibodies production in idiotype induced mouse model of systemic lupus erythematosus'. Together they form a unique fingerprint.

  • Cite this